Meidani Alexandra, Tzavara Chara
Hypervision Laser Centre; Eye Day Clinic; Department of Hygiene, University of Athens Medical School, Centre for Health Services Research, Epidemiology and Medical Statistics, Athens, Greece.
Department of Hygiene, University of Athens Medical School, Centre for Health Services Research, Epidemiology and Medical Statistics, Athens, Greece.
Clin Ophthalmol. 2016 Aug 24;10:1639-46. doi: 10.2147/OPTH.S110626. eCollection 2016.
The main aim of this study was to compare the efficacy, safety, and predictability of femtosecond laser-assisted in situ keratomileusis performed by two different laser suites in the treatment of myopia for up to 6 months.
In this two-site retrospective nonrandomized study, myopic eyes that underwent laser-assisted in situ keratomileusis using IntraLase FS 60 kHz formed group 1 and those using WaveLight FS200 femtosecond laser system formed group 2. Ablation was performed with Visx Star S4 IR and WaveLight EX500 Excimer lasers, respectively, in groups 1 and 2. Both groups were well matched for age, sex, and mean level of preoperative refractive spherical equivalent (MRSE). Uncorrected distance visual acuity, corrected distance visual acuity, and MRSE were evaluated preoperatively and at 1 week, 1 month, and 6 months after treatment.
Fifty-six eyes of 28 patients were included in the study. At 6-month follow-up postop, 78.6% of eyes in group 1 and 92.8% of eyes in group 2 achieved an uncorrected distance visual acuity of 20/20 or better (P=0.252). 35.7% and 50% in group 1 and group 2, respectively, gained one line (P=0.179). No eye lost lines of corrected distance visual acuity. Twenty-five eyes in group 1 (92.7%) and 27 eyes in group 2 (96.3%) had MRSE within ±0.5 D in the 6-month follow-up (P>0.999). The mean efficacy index at 6 months was similar in group 1 and group 2 (mean 1.10±0.12 [standard deviation] vs 1.10±0.1) (P=0.799). The mean safety index was similar in group 1 and group 2 (mean 1.10±0.10 [standard deviation] vs 1.10±0.09) (P=0.407).
The outcomes were excellent between the two laser suites. There were no significant differences at 6-month follow-up postop between the two laser systems.
本研究的主要目的是比较两种不同激光设备进行飞秒激光原位角膜磨镶术治疗近视长达6个月的疗效、安全性和可预测性。
在这项双中心回顾性非随机研究中，使用IntraLase FS 60 kHz进行激光原位角膜磨镶术的近视眼睛形成第1组，使用WaveLight FS200飞秒激光系统的近视眼睛形成第2组。第1组和第2组分别使用Visx Star S4 IR准分子激光和WaveLight EX500准分子激光进行消融。两组在年龄、性别和术前等效球镜平均屈光度（MRSE）方面匹配良好。在术前以及治疗后1周、1个月和6个月评估裸眼远视力、矫正远视力和MRSE。
28例患者的56只眼睛纳入研究。术后6个月随访时，第1组78.6%的眼睛和第2组92.8%的眼睛裸眼远视力达到20/20或更好（P = 0.252）。第1组和第2组分别有35.7%和50%的眼睛视力提高一行（P = 0.179）。没有眼睛的矫正远视力下降。第1组25只眼睛（92.7%）和第2组27只眼睛（96.3%）在6个月随访时MRSE在±0.5 D范围内（P>0.999）。第1组和第2组6个月时的平均疗效指数相似（平均1.10±0.12[标准差]对1.10±0.1）（P = 0.799）。第1组和第2组的平均安全指数相似（平均1.10±0.10[标准差]对1.10±0.09）（P = 0.407）。
两种激光设备的治疗效果均极佳。两种激光系统术后6个月随访时无显著差异。
