Moshirfar Majid, Huynh Rachel, Bundogji Nour, Tukan Alyson N, Sant Thomas M, McCabe Shannon E, West William B, Drennan Kirk, Ronquillo Yasmyne C, Hoopes Phillip C
Hoopes Vision Research Center, Hoopes Vision, Draper, UT 84020, USA.
John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT 84132, USA.
J Clin Med. 2021 Aug 24;10(17):3776. doi: 10.3390/jcm10173776.
Previous studies have demonstrated safety and efficacy using 6.0 and 6.5 mm optical zones in the WaveLight EX500 Excimer Laser System but have not evaluated if differing optical zone sizes influence refractive outcomes. This study examines visual outcomes between two study populations undergoing LASIK with either a 6.0 mm (1332 patients) or 6.5 mm (1332 patients) optical zone. Outcomes were further stratified by severity of myopia (low, moderate, and high) and astigmatism (low and high). Patients were matched by age and preoperative manifest sphere and cylinder. Postoperative measurements were then compared. The 6.5 mm group demonstrated better postoperative manifest refractive spherical equivalent (MRSE), manifest sphere, and absolute value of the difference in actual and target spherical equivalent refraction (|∆ SEQ|), within the total population, moderate myopia, and low astigmatism groups, but this did not lead to improved postoperative uncorrected distance visual acuity (UDVA) or best corrected distance visual acuity (CDVA). Though astigmatic correction and postoperative angle of error were similar between optical zone sizes, they were significantly worse with high myopia. Overall, this study demonstrates differences in visual outcomes between the 6.0 and 6.5 mm optical zone sizes that may warrant consideration; however, essentially, the results are comparable between them.
以往研究已证明，在威视EX500准分子激光系统中使用6.0和6.5毫米的光学区具有安全性和有效性，但尚未评估不同的光学区大小是否会影响屈光结果。本研究调查了接受LASIK手术的两组人群的视觉结果，一组光学区为6.0毫米（1332例患者），另一组为6.5毫米（1332例患者）。结果根据近视程度（低度、中度和高度）和散光程度（低度和高度）进一步分层。患者按年龄、术前明显球镜和柱镜进行匹配。然后比较术后测量结果。在总人群、中度近视和低度散光组中，6.5毫米组术后的明显屈光球镜等效值（MRSE）、明显球镜以及实际与目标球镜等效屈光度差值的绝对值（|∆ SEQ|）更好，但这并未导致术后未矫正远视力（UDVA）或最佳矫正远视力（CDVA）得到改善。虽然不同光学区大小之间的散光矫正和术后误差角度相似，但在高度近视患者中明显更差。总体而言，本研究证明了6.0和6.5毫米光学区大小在视觉结果上存在差异，这可能值得考虑；然而，从本质上讲，两者的结果具有可比性。
