Polich J
Division of Preclinical Neuroscience and Endocrinology, Research Institute of Scripps Clinic, La Jolla, California 92037.
J Clin Neurophysiol. 1989 Jul;6(3):277-86. doi: 10.1097/00004691-198907000-00003.
The auditory event-related potential was assessed in two experiments that evaluated the effects of stimulus factors on P300 (P3) component amplitude and latency. The first experiment manipulated the frequency of the target stimuli (500, 1,000, 1,500, and 2,000 Hz) and standard stimuli (250 and 4,000 Hz) in different conditions. Both P3 amplitude and latency were affected by the target and standard tone combinations in specific ways. The second experiment varied the target tone intensity and duration factorially. P3 amplitude was unaffected by these variables, but peak latency was significantly shorter for the loudest and longest target stimuli. The findings indicate that variation in auditory stimulus parameters can produce small but reliable effects for P3 values, which should be considered when results are compared across studies.
在两项实验中评估了听觉事件相关电位，这两项实验评估了刺激因素对P300（P3）成分幅度和潜伏期的影响。第一个实验在不同条件下操纵了目标刺激（500、1000、1500和2000赫兹）和标准刺激（250和4000赫兹）的频率。P3幅度和潜伏期均以特定方式受到目标音和标准音组合的影响。第二个实验对目标音强度和持续时间进行了析因变化。P3幅度不受这些变量的影响，但对于响度最大和持续时间最长的目标刺激，峰值潜伏期明显更短。研究结果表明，听觉刺激参数的变化可对P3值产生微小但可靠的影响，在跨研究比较结果时应予以考虑。
