• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

放射性出血性膀胱炎的挑战与机遇

Challenges and Opportunities in Radiation-induced Hemorrhagic Cystitis.

作者信息

Zwaans Bernadette M M, Nicolai Heinz G, Chancellor Michael B, Lamb Laura E

机构信息

Department of Urology, William Beaumont Hospital Royal Oak, MI.

出版信息

Rev Urol. 2016;18(2):57-65. doi: 10.3909/riu0700.

DOI:10.3909/riu0700
PMID:27601964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5010626/
Abstract

As diagnosis and treatment of cancer is improving, medical and social issues related to cancer survivorship are becoming more prevalent. Hemorrhagic cystitis (HC), a rare but serious disease that may affect patients after pelvic radiation or systemic chemotherapy, has significant unmet medical needs. Although no definitive treatment is currently available, various interventions are employed for HC. Effects of nonsurgical treatments for HC are of modest success and studies aiming to control radiation-induced bladder symptoms are lacking. In this review, we present current and advanced therapeutic strategies for HC to help cancer survivors deal with long-term urologic health issues.

摘要

随着癌症诊断和治疗水平的提高,与癌症幸存者相关的医学和社会问题日益普遍。出血性膀胱炎(HC)是一种罕见但严重的疾病,可能在盆腔放疗或全身化疗后影响患者,存在重大未满足的医疗需求。尽管目前尚无明确的治疗方法,但针对HC采用了各种干预措施。HC非手术治疗的效果取得了一定成功,但缺乏旨在控制放疗引起的膀胱症状的研究。在本综述中,我们介绍了HC的当前和先进治疗策略,以帮助癌症幸存者应对长期泌尿系统健康问题。

相似文献

1
Challenges and Opportunities in Radiation-induced Hemorrhagic Cystitis.放射性出血性膀胱炎的挑战与机遇
Rev Urol. 2016;18(2):57-65. doi: 10.3909/riu0700.
2
Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies.妇科恶性肿瘤中放疗及出血性膀胱炎相关的癌症生存问题。
Int Urol Nephrol. 2018 Oct;50(10):1745-1751. doi: 10.1007/s11255-018-1970-2. Epub 2018 Aug 21.
3
Advances in Therapeutic Development for Radiation Cystitis.放射性膀胱炎治疗进展
Low Urin Tract Symptoms. 2014 Jan;6(1):1-10. doi: 10.1111/luts.12045. Epub 2013 Dec 23.
4
Treatment of radiation induced hemorrhagic cystitis with hyperbaric oxygen.高压氧治疗放射性出血性膀胱炎
J Urol. 2003 Jun;169(6):2200-2. doi: 10.1097/01.ju.0000063640.41307.c9.
5
Hemorrhagic Cystitis: Making Rapid and Shrewd Clinical and Surgical Decisions for Improving Patient Outcomes.出血性膀胱炎:做出快速且明智的临床和手术决策以改善患者预后。
Res Rep Urol. 2023 Jun 29;15:291-303. doi: 10.2147/RRU.S320684. eCollection 2023.
6
Hemorrhagic cystitis: a review of the literature and treatment options.出血性膀胱炎:文献回顾与治疗选择。
Can J Urol. 2022 Oct;29(5):11276-11283.
7
Heterogeneity in the pharmacological management of radiation-induced hemorrhagic cystitis.放射性出血性膀胱炎的药物治疗的异质性。
Urol Oncol. 2022 Dec;40(12):540.e11-540.e17. doi: 10.1016/j.urolonc.2022.09.006. Epub 2022 Oct 10.
8
Risk factors and predictors of severity score and complications of pediatric hemorrhagic cystitis.儿童出血性膀胱炎严重程度评分和并发症的危险因素和预测因素。
J Urol. 2014 Jan;191(1):186-92. doi: 10.1016/j.juro.2013.08.007. Epub 2013 Aug 13.
9
Hyperbaric oxygen therapy for radiation induced hemorrhagic cystitis.高压氧疗法治疗放射性出血性膀胱炎
J Urol. 1999 Feb;161(2):435-7.
10
Hyperbaric oxygen therapy for radiation-induced cystitis and proctitis.高压氧治疗放射性膀胱炎和直肠炎。
Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):733-40. doi: 10.1016/j.ijrobp.2011.12.056. Epub 2012 Mar 21.

引用本文的文献

1
Urinary Metabolites as Biomarkers of Early Radiation Cystitis in Patients With Prostate Cancer Undergoing Radiotherapy.尿代谢产物作为接受放疗的前列腺癌患者早期放射性膀胱炎的生物标志物
In Vivo. 2025 Jul-Aug;39(4):2091-2100. doi: 10.21873/invivo.14004.
2
Clinical Guidelines for the Prevention and Treatment of Radiation-induced Bladder Injury.放射性膀胱损伤防治临床指南
Precis Radiat Oncol. 2024 Feb 8;8(1):4-13. doi: 10.1002/pro6.1215. eCollection 2024 Mar.
3
Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): long-term follow-up of a randomised controlled, phase 2-3 trial.高压氧疗法治疗放射性膀胱炎(RICH-ART):一项随机对照2-3期试验的长期随访
EClinicalMedicine. 2025 Apr 19;83:103214. doi: 10.1016/j.eclinm.2025.103214. eCollection 2025 May.
4
Case report: Successful treatment of hyperbaric oxygen for radiation-induced hemorrhagic cystitis in a 95-year-old patient with bladder cancer.病例报告:高压氧成功治疗一名95岁膀胱癌患者的放射性出血性膀胱炎。
Front Oncol. 2025 Feb 3;15:1410148. doi: 10.3389/fonc.2025.1410148. eCollection 2025.
5
Advancements in Understanding and Managing Radiation Cystitis: A Comprehensive Review.深入了解和管理放射性膀胱炎:全面综述。
Curr Urol Rep. 2024 Sep 17;26(1):1. doi: 10.1007/s11934-024-01238-0.
6
The effect of myeloablative radiation on urinary bladder mast cells.骨髓清除性放疗对膀胱肥大细胞的影响。
Sci Rep. 2024 Mar 14;14(1):6219. doi: 10.1038/s41598-024-56655-5.
7
Identification of Molecular Mechanisms in Radiation Cystitis: Insights from RNA Sequencing.放射性膀胱炎分子机制的鉴定:来自RNA测序的见解
Int J Mol Sci. 2024 Feb 23;25(5):2632. doi: 10.3390/ijms25052632.
8
Cystoscopic application of PuraStat in the treatment of radiation-induced haemorrhagic cystitis.膀胱镜下应用PuraStat治疗放射性出血性膀胱炎。
Ann R Coll Surg Engl. 2025 Mar;107(3):230-232. doi: 10.1308/rcsann.2023.0034. Epub 2024 Feb 16.
9
Slightly photo-crosslinked chitosan/silk fibroin hydrogel adhesives with hemostasis and anti-inflammation for pro-healing cyclophosphamide-induced hemorrhagic cystitis.具有止血和抗炎作用的轻度光交联壳聚糖/丝素蛋白水凝胶粘合剂用于促进环磷酰胺诱导的出血性膀胱炎的愈合
Mater Today Bio. 2024 Jan 5;25:100947. doi: 10.1016/j.mtbio.2024.100947. eCollection 2024 Apr.
10
The effects of radiation on myeloid lineage immune cells within the rodent urinary bladder: a systematic review.辐射对啮齿动物膀胱内髓系免疫细胞的影响:系统评价。
Int Urol Nephrol. 2023 Dec;55(12):3005-3014. doi: 10.1007/s11255-023-03748-1. Epub 2023 Aug 24.

本文引用的文献

1
Modeling and Treatment of Radiation Cystitis.放射性膀胱炎的建模与治疗
Urology. 2016 Feb;88:14-21. doi: 10.1016/j.urology.2015.11.001. Epub 2015 Nov 10.
2
Innovative use of intravesical tacrolimus for hemorrhagic radiation cystitis.膀胱内使用他克莫司治疗出血性放射性膀胱炎的创新应用。
Int Urol Nephrol. 2015 Oct;47(10):1679-81. doi: 10.1007/s11255-015-1098-6. Epub 2015 Sep 7.
3
Intravesical Liposomal Tacrolimus Protects against Radiation Cystitis Induced by 3-Beam Targeted Bladder Radiation.膀胱内脂质体他克莫司可预防三束靶向膀胱放疗引起的放射性膀胱炎。
J Urol. 2015 Aug;194(2):578-84. doi: 10.1016/j.juro.2015.03.108. Epub 2015 Apr 1.
4
Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells.钙调神经磷酸酶抑制剂通过直接作用于初始B细胞来抑制体液免疫。
Clin Exp Immunol. 2015 Jun;180(3):542-50. doi: 10.1111/cei.12604.
5
Chemical- and radiation-induced haemorrhagic cystitis: current treatments and challenges.化学和辐射诱导的出血性膀胱炎:当前的治疗方法和挑战。
BJU Int. 2013 Nov;112(7):885-97. doi: 10.1111/bju.12291.
6
Formulation strategies for drug delivery of tacrolimus: An overview.他克莫司药物递送的制剂策略:综述
Int J Pharm Investig. 2012 Oct;2(4):169-75. doi: 10.4103/2230-973X.106981.
7
Development of potential orphan drug therapy of intravesical liposomal tacrolimus for hemorrhagic cystitis due to increased local drug exposure.为增加局部药物暴露而开发潜在的用于治疗出血性膀胱炎的膀胱内脂质体他克莫司孤儿药疗法。
J Urol. 2013 Apr;189(4):1553-8. doi: 10.1016/j.juro.2012.10.123. Epub 2012 Nov 2.
8
Hyperbaric oxygen therapy for radiation-induced cystitis and proctitis.高压氧治疗放射性膀胱炎和直肠炎。
Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):733-40. doi: 10.1016/j.ijrobp.2011.12.056. Epub 2012 Mar 21.
9
Botulinum toxin injections for adults with overactive bladder syndrome.肉毒杆菌毒素注射治疗成人膀胱过度活动症
Cochrane Database Syst Rev. 2011 Dec 7(12):CD005493. doi: 10.1002/14651858.CD005493.pub3.
10
Effect of botulinum toxin on expression of nerve growth factor and transient receptor potential vanilloid 1 in urothelium and detrusor muscle of rats with bladder outlet obstruction-induced detrusor overactivity.肉毒毒素对膀胱出口梗阻性逼尿肌过度活动大鼠膀胱上皮和逼尿肌中神经生长因子和瞬时受体电位香草素 1 表达的影响。
Urology. 2011 Sep;78(3):721.e1-721.e6. doi: 10.1016/j.urology.2011.03.070. Epub 2011 Jul 22.