Rambhatla Amarnath, Mills Jesse N, Rajfer Jacob
Department of Urology, David Geffen School of Medicine at UCLA Los Angeles, CA.
Rev Urol. 2016;18(2):66-72. doi: 10.3909/riu0711.
Estradiol, normally considered a female hormone, appears to play a significant role in men in a variety of physiologic functions, such as bone metabolism, cardiovascular health, and testicular function. As such, estradiol has been targeted by male reproductive and sexual medicine specialists to help treat conditions such as infertility and hypogonadism. The compounds that modulate estradiol levels in these clinical conditions are referred to as selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs). In a certain subset of infertile men, particularly those with hypogonadism, or those who have a low serum testosterone to estradiol ratio, there is some evidence suggesting that SERMs and AIs can reverse the low serum testosterone levels or the testosterone to estradiol imbalance and occasionally improve any associated infertile or subfertile state. This review focuses on the role these SERMs and AIs play in the aforementioned reproductive conditions.
雌二醇通常被认为是一种女性激素，但它似乎在男性的多种生理功能中发挥着重要作用，如骨骼代谢、心血管健康和睾丸功能。因此，男性生殖与性医学专家将雌二醇作为治疗不育症和性腺功能减退等病症的靶点。在这些临床病症中调节雌二醇水平的化合物被称为选择性雌激素受体调节剂（SERM）和芳香化酶抑制剂（AI）。在一部分不育男性中，尤其是那些患有性腺功能减退症的男性，或者血清睾酮与雌二醇比值较低的男性，有证据表明SERM和AI可以逆转血清睾酮水平低下或睾酮与雌二醇失衡的状况，偶尔还能改善任何相关的不育或亚不育状态。本综述重点关注这些SERM和AI在上述生殖病症中所起的作用。
