Majzoub Ahmad, Sabanegh Edmund
Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Transl Androl Urol. 2016 Dec;5(6):859-865. doi: 10.21037/tau.2016.08.03.
Hypogonadism is a common clinical condition affecting men of different age groups. In addition to its sexual consequences, it has several implications posing significant concerns for a man's health and well-being. Recent advances in testosterone (T) supplementation have facilitated hypogonadism treatment. Despite that, patients complaining of infertility or seeking conception are still hindered by the unfavorable effects supplemental T has on testicular function. Consequently, alternative approaches that can stimulate endogenous T production are favored. Selective estrogen receptor modulators, gonadotropins and aromatase inhibitors (AIs) can be successful in restoring serum T levels, preserving fertility, and providing symptomatic relief.
性腺功能减退是一种影响不同年龄组男性的常见临床病症。除了其对性功能的影响外，它还具有若干影响，对男性的健康和福祉构成重大担忧。睾酮（T）补充疗法的最新进展促进了性腺功能减退的治疗。尽管如此，抱怨不育或寻求受孕的患者仍然受到补充T对睾丸功能的不利影响的阻碍。因此，能够刺激内源性T产生的替代方法受到青睐。选择性雌激素受体调节剂、促性腺激素和芳香化酶抑制剂（AIs）在恢复血清T水平、保持生育能力和缓解症状方面可能会取得成功。
