Jacob Mini E, Yee Laura M, Diehr Paula H, Arnold Alice M, Thielke Stephen M, Chaves Paulo H M, Gobbo Liana Del, Hirsch Calvin, Siscovick David, Newman Anne B
Geriatric Research, Education, and Clinical Center, Boston, Massachusetts.
Health and Disability Research Institute, School of Public Health, Boston University, Boston, Massachusetts.
J Am Geriatr Soc. 2016 Oct;64(10):1952-1961. doi: 10.1111/jgs.14314. Epub 2016 Sep 7.
To determine whether lifestyle factors, measured late in life, could compress the disabled period toward the end of life.
Community-based cohort study of older adults followed from 1989 to 2015.
Four U.S. communities.
Community-living men and women aged 65 and older (N = 5,248, mean age 72.7 ± 5.5, 57% female, 15.2% minority) who were not wheelchair dependent and were able to give informed consent at baseline.
Multiple lifestyle factors, including smoking, alcohol consumption, physical activity, diet, body mass index (BMI), social networks, and social support, were measured at baseline. Activities of daily living (ADLs) were assessed at baseline and throughout follow-up. Years of life (YoL) was defined as years until death. Years of able life (YAL) was defined as years without any ADL difficulty. YAL/YoL%, the proportion of life lived able, was used to indicate the relative compression or expansion of the disabled period.
The average duration of disabled years was 4.5 (out of 15.4 mean YoL) for women and 2.9 (out of 12.4 mean YoL) for men. In a multivariable model, obesity was associated with 7.3 percentage points (95% confidence interval (CI) = 5.4-9.2) lower YAL/YoL% than normal weight. Scores in the lowest quintile of the Alternate Healthy Eating Index were associated with a 3.7% (95% CI = 1.6-5.9) lower YAL/YoL% than scores in the highest quintile. Every 25 blocks walked in a week was associated with 0.5 percentage points (95% CI = 0.3-0.8) higher YAL/YoL%.
The effects of healthy lifestyle factors on the proportion of future life lived free of disability indicate that the disabled period can be compressed, given the right combination of these factors.
确定在生命后期测量的生活方式因素是否能将残疾期压缩至生命末期。
1989年至2015年对老年人进行的基于社区的队列研究。
美国四个社区。
年龄在65岁及以上的社区居住男性和女性(N = 5248,平均年龄72.7±5.5,57%为女性,15.2%为少数族裔),他们不依赖轮椅且在基线时能够给予知情同意。
在基线时测量多种生活方式因素,包括吸烟、饮酒、身体活动、饮食、体重指数(BMI)、社交网络和社会支持。在基线和整个随访期间评估日常生活活动(ADL)。生命年数(YoL)定义为直至死亡的年数。无残疾生命年数(YAL)定义为没有任何ADL困难的年数。YAL/YoL%,即无残疾生活的生命比例,用于表明残疾期的相对压缩或延长。
女性残疾年的平均持续时间为4.5年(平均YoL为15.4年),男性为2.9年(平均YoL为12.4年)。在多变量模型中,肥胖与YAL/YoL%比正常体重低7.3个百分点(95%置信区间(CI)= 5.4 - 9.2)相关。替代健康饮食指数最低五分位数的得分与YAL/YoL%比最高五分位数的得分低3.7%(95% CI = 1.6 - 5.9)相关。每周步行每25个街区与YAL/YoL%高0.5个百分点(95% CI = 0.3 - 0.8)相关。
健康生活方式因素对未来无残疾生活比例的影响表明,鉴于这些因素的正确组合,残疾期可以被压缩。