Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Institute of Biomedical Engineering, University of Oxford, Old Road Campus, Oxford, United Kingdom.
Magn Reson Med. 2017 Aug;78(2):541-549. doi: 10.1002/mrm.26388. Epub 2016 Sep 8.
A novel method for quantitative measurement of myocardial blood flow (MBF) using arterial spin labeling (ASL) in a single breath-hold is presented, evaluated by simulations, phantom studies and in vivo studies and tested for reproducibility and variability.
A flow-sensitive alternating inversion recovery (FAIR) ASL method with Look-Locker readout (LL-FAIR-ASL) was implemented at 3 tesla. Scans were performed on 10 healthy volunteers and MBF measured in three slices. The method was investigated for reproducibility by Bland-Altman analysis and statistical measures, the coefficients of reproducibility (CR) and variation (CV) are reported.
The MBF values for the basal, mid, and apical slices were 1.04 ± 0.40, 1.06 ± 0.46, and 1.06 ± 0.38 ml/g/min, respectively (mean ± SD), which compare well with literature values. The CV across all scans, 43%, was greater than the between-session and within-session values, at 16 and 13%, respectively, for the mid-ventricular slice. The change in MBF required for detection, from the CR, was 61% between-session and 53% within-session for the mid-ventricle.
This study shows the feasibility of the LL-FAIR-ASL method for the quantification of MBF. The statistical measures reported will allow the planning of future clinical research studies involving rest and stress measurements. Magn Reson Med 78:541-549, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
提出了一种使用动脉自旋标记（ASL）在单次屏气中定量测量心肌血流（MBF）的新方法，通过模拟、体模研究和体内研究进行了评估，并测试了其可重复性和变异性。
在 3T 上实现了带有 Look-Locker 读取（LL-FAIR-ASL）的流量敏感反转恢复（FAIR）ASL 方法。在 10 名健康志愿者中进行了扫描，并在三个切片中测量了 MBF。通过 Bland-Altman 分析和统计措施评估了方法的可重复性，报告了可重复性系数（CR）和变异性（CV）。
基底、中部和顶部切片的 MBF 值分别为 1.04±0.40、1.06±0.46 和 1.06±0.38ml/g/min（平均值±标准差），与文献值相符。所有扫描的 CV（43%）大于两次扫描之间和一次扫描内的 CV，分别为 16%和 13%，对于中部心室切片。从中获得的 CR 检测到的 MBF 变化为两次扫描之间为 61%，一次扫描内为 53%，对于中部心室。
本研究表明，LL-FAIR-ASL 方法可用于定量测量 MBF。报告的统计措施将允许规划涉及休息和应激测量的未来临床研究。磁共振医学 78:541-549，2017。© 2016 作者磁共振医学由 Wiley 期刊出版公司代表国际磁共振学会出版。这是根据知识共享署名许可条款允许在任何媒介中使用、分发和复制原始作品的许可，只要原始作品正确引用。
