Fich A, Camilleri M, Phillips S F
Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN 55905.
J Clin Gastroenterol. 1989 Aug;11(4):416-20. doi: 10.1097/00004836-198908000-00014.
To test the hypothesis that age alters fasting and postprandial antral and intestinal motility in humans, we studied 23 patients, aged 18-39 years (median 28), and 13 patients, aged 40-69 years (median 49). All were having gastrointestinal symptoms, but in none was there objective clinical, radiologic, or endoscopic features of bowel disease, and manometry of the stomach and proximal small bowel was normal. We quantitated certain parameters of fasting intestinal motility and postprandial antral and jejunal motility. There were no significant differences in the interval between interdigestive motor complexes (IMC), duration, propagation velocity, or maximum number of contractions during phase III of the IMC, or postprandial antral and jejunal motility indices. The postprandial indices show a very similar distribution in each decade. Thus, in selected patients with unexplained gastrointestinal symptoms but no objective features of gut disease, quantifiable gastric and small bowel motility parameters do not differ in the age groups 18-39 and 40-69 years.
为了验证年龄会改变人类空腹及餐后胃窦和肠道运动这一假设，我们研究了23名年龄在18至39岁（中位数28岁）的患者以及13名年龄在40至69岁（中位数49岁）的患者。所有患者均有胃肠道症状，但均无肠道疾病的客观临床、放射学或内镜特征，且胃和近端小肠的测压结果正常。我们对空腹肠道运动以及餐后胃窦和空肠运动的某些参数进行了定量分析。消化间期移行性复合波（IMC）之间的间隔、持续时间、传播速度、IMC第三相期间的最大收缩次数，或餐后胃窦和空肠运动指数均无显著差异。餐后指数在每个十年中的分布非常相似。因此，在选定的有不明原因胃肠道症状但无肠道疾病客观特征的患者中，18至39岁和40至69岁年龄组的可量化胃和小肠运动参数并无差异。
