Davey C G, López-Solà C, Bui M, Hopper J L, Pantelis C, Fontenelle L F, Harrison B J
Orygen, The National Centre of Excellence in Youth Mental Health,Melbourne,Australia.
Adult Mental Health Unit,Parc Taulí University Hospital,Sabadell,Spain.
Psychol Med. 2016 Nov;46(15):3213-3218. doi: 10.1017/S0033291716001884. Epub 2016 Sep 8.
Negative mood states are composed of symptoms of depression and anxiety, and by a third factor related to stress, tension and irritability. We sought to clarify the nature of the relationships between the factors by studying twin pairs.
A total of 503 monozygotic twin pairs completed the Depression Anxiety Stress Scales (DASS), an instrument that assesses symptoms of depression, anxiety and stress-tension. We applied a recently developed twin regression methodology - Inference about Causation from Examination of FAmiliaL CONfounding (ICE FALCON) - to test for evidence consistent with the existence of 'causal' influences between the DASS factors.
There was evidence consistent with the stress-tension factor having a causal influence on both the depression (p < 0.0001) and anxiety factors (p = 0.001), and for the depression factor having a causal influence on the anxiety factor (p < 0.001).
Our findings suggest a critical role for stress-tension in the structure of negative mood states, and that interventions that target it may be particularly effective in reducing depression and anxiety symptoms.
消极情绪状态由抑郁和焦虑症状以及与压力、紧张和易怒相关的第三个因素组成。我们试图通过研究双胞胎对来阐明这些因素之间关系的本质。
总共503对同卵双胞胎完成了抑郁焦虑压力量表（DASS），这是一种评估抑郁、焦虑和压力紧张症状的工具。我们应用了最近开发的双胞胎回归方法——通过检查家族混杂因素进行因果推断（ICE FALCON）——来检验与DASS因素之间存在“因果”影响相一致的证据。
有证据表明压力紧张因素对抑郁因素（p < 0.0001）和焦虑因素（p = 0.001）均有因果影响，且抑郁因素对焦虑因素有因果影响（p < 0.001）。
我们的研究结果表明压力紧张在消极情绪状态结构中起关键作用，针对它的干预措施可能在减轻抑郁和焦虑症状方面特别有效。
