Telethon Kids Institute, The University of Western Australia.
School of Psychology, The University of Western Australia.
J Abnorm Psychol. 2016 Jan;125(1):1-10. doi: 10.1037/abn0000119. Epub 2015 Nov 16.
The evidence regarding older parental age and incidence of mood disorder symptoms in offspring is limited, and that which exists is mixed. We sought to clarify these relationships by using data from the Western Australian Pregnancy Cohort (Raine) Study. The Raine Study provided comprehensive data from 2,900 pregnancies, resulting in 2,868 live born children. A total of 1,220 participants completed the short form of the Depression Anxiety Stress Scale (DASS-21) at the 20-year cohort follow-up. We used negative binomial regression analyses with log link and with adjustment for known perinatal risk factors to examine the extent to which maternal and paternal age at childbirth predicted continuous DASS-21 index scores. In the final multivariate models, a maternal age of 30-34 years was associated with significant increases in stress DASS-21 scores in female offspring relative to female offspring of 25- to 29-year-old mothers. A maternal age of 35 years and over was associated with increased scores on all DASS-21 scales in female offspring. Our results indicate that older maternal age is associated with depression, anxiety, and stress symptoms in young adult females. Further research into the mechanisms underpinning this relationship is needed.
关于年长父母年龄与后代情绪障碍症状发生率的证据有限，而且存在的证据相互矛盾。我们试图通过使用西澳大利亚妊娠队列（Raine）研究的数据来澄清这些关系。Raine 研究从 2900 例妊娠中提供了全面的数据，其中 2868 例为活产儿。共有 1220 名参与者在 20 年队列随访时完成了抑郁焦虑压力量表（DASS-21）的简短形式。我们使用具有对数链接的负二项式回归分析，并调整了已知的围产期风险因素，以检查分娩时母亲和父亲的年龄在多大程度上预测了 DASS-21 指数得分的连续变化。在最终的多变量模型中，与 25 至 29 岁母亲的女儿相比，30 至 34 岁母亲的女儿的压力 DASS-21 评分显著升高。母亲年龄为 35 岁及以上与女儿在所有 DASS-21 量表上的评分升高有关。我们的研究结果表明，年长的母亲年龄与年轻成年女性的抑郁、焦虑和压力症状有关。需要进一步研究这种关系背后的机制。
