Hayashi Y, Hattori Y, Moriwaki A, Saeki K, Hori Y
Department of Physiology, Okayama University Medical School, Japan.
J Neurochem. 1989 Sep;53(3):986-8. doi: 10.1111/j.1471-4159.1989.tb11805.x.
Concentrations of the polyamines putrescine, spermidine, and spermine were investigated in the left and right amygdala and in the remaining cerebrum, in which kindling was induced by repeated application of electrical stimulation of the left amygdala of rats. In kindled rats, the concentrations of spermidine and spermine increased slightly, but elevations did not reach significant levels in any brain regions. The most profound increase was detected in the putrescine concentration in all parts of the cerebrum 1-8 h after the final stimulation. These results suggest that the increases in concentrations of polyamines, particularly of putrescine, are involved in the pathogenesis of amygdaloid kindling.
在大鼠左侧杏仁核反复进行电刺激以诱导点燃，在此基础上，研究了多胺腐胺、亚精胺和精胺在左右杏仁核以及其余大脑组织中的浓度。在点燃的大鼠中，亚精胺和精胺的浓度略有增加，但在任何脑区中升高均未达到显著水平。在最后一次刺激后1 - 8小时，在大脑所有部位的腐胺浓度检测到最显著的增加。这些结果表明，多胺浓度的增加，尤其是腐胺，参与了杏仁核点燃的发病机制。
