Meyers S A, Seaber A V, Glisson R R, Nunley J A
Duke University Medical Center, Orthopaedic Research Laboratories, Durham, North Carolina 27710.
J Orthop Res. 1989;7(5):683-9. doi: 10.1002/jor.1100070508.
Viscoat, a high-molecular-weight, highly purified hyaluronic acid (HA) and chondroitin sulfate (CS) compound, was instilled around rabbit plantaris tendon following full-thickness laceration and surgical repair. After 3 weeks of immobilization, no significant difference in adhesion strength or tensile strength of the healing tendons existed between Viscoat-treated tendons and controls. This contradicts previous studies which suggest that hyaluronic acid reduces postoperative tendon adhesions. Further studies examining tendon adhesions after less severe degrees of tendon injury and using direct, quantitative measurement techniques are warranted to demonstrate whether HA has a beneficial effect on tendon healing.
维视可（Viscoat）是一种高分子量、高度纯化的透明质酸（HA）与硫酸软骨素（CS）的化合物，在兔跖肌腱全层撕裂并进行手术修复后，将其滴注于肌腱周围。固定3周后，接受维视可治疗的肌腱与对照组相比，愈合肌腱的粘连强度或拉伸强度没有显著差异。这与之前的研究结果相矛盾，之前的研究表明透明质酸可减少术后肌腱粘连。有必要进行进一步研究，以检查较轻程度肌腱损伤后的肌腱粘连情况，并采用直接、定量的测量技术，来证明透明质酸对肌腱愈合是否具有有益作用。
