胎盘生长因子：血液学家需要了解的内容。
Placental growth factor: What hematologists need to know.
作者信息
Newell Laura F, Holtan Shernan G
机构信息
Oregon Health and Science University, Center for Hematologic Malignancies, Portland, OR, USA.
University of Minnesota, Blood and Marrow Transplant Program, Minneapolis, MN, USA.
出版信息
Blood Rev. 2017 Jan;31(1):57-62. doi: 10.1016/j.blre.2016.08.004. Epub 2016 Aug 27.
Abstract
Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood diseases including hemoglobinopathies and hematologic malignancies. Therapies for such blood diseases may one day be based upon these and ongoing investigations into the role of PlGF in sickle cell disease, acute and chronic leukemias, and complications related to hematopoietic cell transplantation. In this review, we summarize recent studies regarding the potential role of PlGF in blood disorders and suggest avenues for future research.
摘要
血管生成因子胎盘生长因子（PlGF）虽然最初是在胎盘中发现的，但它可以在缺血或受损组织中广泛表达。最近的研究表明，PlGF是包括血红蛋白病和血液系统恶性肿瘤在内的血液疾病病理生物学中的一个相关因素。这类血液疾病的治疗方法可能有一天会基于这些研究以及对PlGF在镰状细胞病、急慢性白血病和造血细胞移植相关并发症中作用的持续研究。在这篇综述中，我们总结了关于PlGF在血液疾病中潜在作用的最新研究，并提出了未来研究的方向。
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