Giusti Laura, Sernissi Francesca, Donadio Elena, Ciregia Federica, Giacomelli Camillo, Giannaccini Gino, Mazzoni Maria Rosa, Lucacchini Antonio, Bazzichi Laura
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
J Transl Med. 2016 Sep 8;14(1):262. doi: 10.1186/s12967-016-1023-5.
Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and the internal organs. In a previous work we suggested a correlation between levels of salivary psoriasin (S100A7) and pulmonary involvement in SSc patients. The goals of this study are to determine the distribution characteristics of psoriasin in whole saliva (WS) of SSc and healthy donor populations and define its predictive value on diffusion capacity of carbon monoxide (DLCO), along with others clinical parameters.
Salivary level of psoriasin was determined by ELISA kit in 134 SSc patients, 63 Raynaud syndrome patients, 40 patients affected by other connective diseases (non-case) and 74 healthy control subjects.
A significant increase of salivary psoriasin was observed in SSc patients when compared with other healthy and pathological controls. Moreover, we confirmed the efficacy of salivary psoriasin to correlate with DLCO in a large cohort of SSc patients.
Overall our results suggest a rapid, non invasive and low costing method which can help clinicians in the evaluation of SSc pulmonary involvement.
系统性硬化症（SSc）是一种自身免疫性疾病，其特征为皮肤和内脏进行性纤维化。在之前的一项研究中，我们提出唾液中银屑素（S100A7）水平与SSc患者肺部受累之间存在关联。本研究的目的是确定银屑素在SSc患者和健康供体人群全唾液（WS）中的分布特征，并确定其对一氧化碳弥散量（DLCO）以及其他临床参数的预测价值。
采用酶联免疫吸附测定（ELISA）试剂盒测定134例SSc患者、63例雷诺综合征患者、40例其他结缔组织病患者（非病例组）和74例健康对照者唾液中银屑素水平。
与其他健康和病理对照组相比，SSc患者唾液中银屑素水平显著升高。此外，我们在一大群SSc患者中证实了唾液中银屑素与DLCO相关的有效性。
总体而言，我们的结果提示了一种快速、无创且低成本的方法，可帮助临床医生评估SSc患者的肺部受累情况。
