Stehr-Green P A
Centers for Disease Control, Department of Health and Human Services, Atlanta, Georgia 30333.
J Toxicol Environ Health. 1989;27(4):405-21. doi: 10.1080/15287398909531312.
This study was intended to characterize more fully the distribution of serum concentrations of 16 pesticide residues with regard to key demographic and seasonal variables in a subsample of persons from the Second National Health and Nutrition Examination Survey between the ages of 12 and 74 yr old. Blood sera in 2-ml aliquots were analyzed, and the results were confirmed for 5994 persons. Almost all participants (99.5%) had p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) concentrations greater than or equal to 1 ppb, ranging as high as 378.6 ppb. For the other pesticide residues, only beta-benzene hexachloride (beta-BHC) (quantified in 17.2% of the sera), dieldrin (10.6%), and another DDT-related residue, p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) (35.7%) were found at quantifiable levels in more than 10% of the serum specimens. Of the remaining analytes, hexachlorobenzene (HCB), trans-nonachlor (TNC), and heptachlor epoxide (HE) were found at quantifiable concentrations in 1-10% of the specimens, whereas o,p'-DDT, o,p'-DDE, p,p'-DDD, mirex, alpha-BHC, gamma-BHC, heptachlor, delta-BHC, and aldrin were found in less than 1% of the serum specimens. Results showed that increasing age, residing on a farm, or being a male conferred increased risks of exposure to most of the pesticide residues, independent of all other demographic and seasonal factors. In a pattern less consistent across the different pesticide residues and for fewer of the pesticides, persons who lived below the national poverty level, were nonwhite, resided in the South or West, or were examined in the spring or winter also seemed to have an increased likelihood of having quantifiable serum levels.
本研究旨在更全面地描述16种农药残留的血清浓度分布情况，这些农药残留与第二次全国健康与营养检查调查中12至74岁子样本人群的关键人口统计学和季节变量有关。对2毫升等分血清样本进行了分析，结果在5994人身上得到了证实。几乎所有参与者（99.5%）的对，对'-二氯二苯二氯乙烯（p，p'-DDE）浓度大于或等于1 ppb，最高可达378.6 ppb。对于其他农药残留，只有β-六六六（β-BHC）（在17.2%的血清中被定量）、狄氏剂（10.6%）以及另一种与滴滴涕相关的残留，对，对'-二氯二苯三氯乙烷（p，p'-DDT）（35.7%）在超过10%的血清样本中被检测到可量化水平。在其余分析物中，六氯苯（HCB）、反式九氯（TNC）和七氯环氧化物（HE）在1%-10%的样本中被检测到可量化浓度，而邻，对'-DDT、邻，对'-DDE、对，对'-DDD、灭蚁灵、α-六六六、γ-六六六、七氯、δ-六六六和艾氏剂在不到1%的血清样本中被检测到。结果表明，年龄增长、居住在农场或为男性会增加接触大多数农药残留的风险，这与所有其他人口统计学和季节因素无关。在不同农药残留中一致性较差且涉及的农药较少的一种模式中，生活在国家贫困线以下、非白人、居住在南部或西部或在春季或冬季接受检查的人似乎也更有可能有可量化的血清水平。
