新型基于聚乙烯醇-生物活性玻璃45S5的复合纳米纤维膜作为骨支架
Novel polyvinyl alcohol-bioglass 45S5 based composite nanofibrous membranes as bone scaffolds.
作者信息
Shankhwar Nisha, Kumar Manishekhar, Mandal Biman B, Srinivasan A
机构信息
Department of Physics, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.
出版信息
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:1167-74. doi: 10.1016/j.msec.2016.08.018. Epub 2016 Aug 9.
Composite nanofibrous membranes based on sol-gel derived 45SiO2 24.5CaO 24.5 Na2O 6 P2O5 (bioglass, BG) and 43SiO2 24.5CaO 24.5 Na2O 6 P2O5 2Fe2O3 (magnetic bioglass, MBG) blended with polyvinyl alcohol (PVA) have been electrospun. These low cost membranes were mostly amorphous in structure with minor crystalline (sodium calcium phosphate) precipitates. All membranes were biodegradable. Among these, the composites exhibited higher tensile strength, better proliferation of human osteosarcoma MG63 cells and higher alkaline phosphatase enzyme activity than the bare PVA membrane, indicating their potential in bone tissue engineering. The magnetic PVA-MBG scaffold was also found to be a promising candidate for magnetic hyperthermia application.
基于溶胶 - 凝胶法制备的45SiO₂ 24.5CaO 24.5Na₂O 6P₂O₅（生物玻璃，BG）和43SiO₂ 24.5CaO 24.5Na₂O 6P₂O₅ 2Fe₂O₃（磁性生物玻璃，MBG）与聚乙烯醇（PVA）混合的复合纳米纤维膜已通过静电纺丝制备而成。这些低成本的膜在结构上大多为非晶态，伴有少量结晶（磷酸钠钙）沉淀。所有膜都具有生物可降解性。其中，与纯PVA膜相比，复合材料表现出更高的拉伸强度、人骨肉瘤MG63细胞更好的增殖能力以及更高的碱性磷酸酶活性，表明它们在骨组织工程中的潜力。磁性PVA - MBG支架也被发现是磁热疗应用的一个有前景的候选材料。
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