Xu Chenxi, Cheng Pengzhen, Wang Junxiang, Zhang Beilei, Shang Peng, Lv Yi, Jie Qiang
Pediatric Hospital, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
College of Life Sciences, Northwest University, Xi'an, China.
Research (Wash D C). 2025 May 22;8:0707. doi: 10.34133/research.0707. eCollection 2025.
To improve the treatment outcomes for large bone defects and osteoporosis, researchers have been committed to reducing bone loss and accelerating bone regeneration through cell transplantation, biomaterial intervention, and biophysical stimulation over the past few decades. Magnetism, as a noninvasive biophysical stimulus, has been employed in the repair of the musculoskeletal system, achieving a series of promising results. In this review, we provide a retrospective analysis and perspective of research on magnetic-driven bone regeneration and functional reconstruction. This review aims to delineate safe and efficient magnetic application modalities and to summarize the potential mechanisms by which magnetism regulates the behavior of skeletal lineage cells, thereby providing insights for the expansion and translational application of magnetic-driven regenerative medicine.
在过去几十年里，为了改善大型骨缺损和骨质疏松症的治疗效果，研究人员一直致力于通过细胞移植、生物材料干预和生物物理刺激来减少骨质流失并加速骨再生。磁作为一种非侵入性生物物理刺激，已被应用于肌肉骨骼系统的修复，并取得了一系列令人鼓舞的成果。在本综述中，我们对磁驱动骨再生和功能重建的研究进行了回顾性分析并展望未来。本综述旨在阐明安全有效的磁应用模式，并总结磁调节骨骼谱系细胞行为的潜在机制，从而为磁驱动再生医学的扩展和转化应用提供见解。
