Patten Christi A, Bronars Carrie A, Vickers Douglas Kristin S, Ussher Michael H, Levine James A, Tye Susannah J, Hughes Christine A, Brockman Tabetha A, Decker Paul A, DeJesus Ramona S, Williams Mark D, Olson Thomas P, Clark Matthew M, Dieterich Angela M
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN;
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
Nicotine Tob Res. 2017 Jan;19(1):77-86. doi: 10.1093/ntr/ntw208. Epub 2016 Sep 9.
Few studies have evaluated exercise interventions for smokers with depression or other psychiatric comorbidities. This pilot study evaluated the potential role of supervised vigorous exercise as a smoking cessation intervention for depressed females.
Thirty adult women with moderate-severe depressive symptoms were enrolled and randomly assigned to 12 weeks of thrice weekly, in person sessions of vigorous intensity supervised exercise at a YMCA setting (EX; n = 15) or health education (HE; n = 15). All participants received behavioral smoking cessation counseling and nicotine patch therapy. Assessments were done in person at baseline, at the end of 12 weeks of treatment, and at 6 months post-target quit date. Primary end points were exercise adherence (proportion of 36 sessions attended) and biochemically confirmed 7-day point prevalence abstinence at Week 12. Biomarkers of inflammation were explored for differences between treatment groups and between women who smoked and those abstinent at Week 12.
Treatment adherence was high for both groups (72% for EX and 66% for HE; p = .55). The Week 12 smoking abstinence rate was higher for EX than HE (11/15 [73%] vs. 5/15 [33%]; p = .028), but no significant differences emerged at 6-month follow-up. Interleukin-6 levels increased more for those smoking than women abstinent at Week 12 (p = .040).
Vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. Innovative and cost-effective strategies to bolster long-term exercise adherence and smoking cessation need evaluation in this population. Inflammatory biomarkers could be examined in future research as mediators of treatment efficacy.
This preliminary study found that vigorous intensity supervised exercise is feasible and enhances short-term smoking cessation among depressed female smokers. This research addressed an important gap in the field. Despite decades of research examining exercise interventions for smoking cessation, few studies were done among depressed smokers or those with comorbid psychiatric disorders. A novel finding was increases in levels of a pro-inflammatory biomarker observed among women who smoked at the end of the intervention compared to those who did not.
很少有研究评估针对患有抑郁症或其他精神疾病合并症的吸烟者的运动干预措施。这项初步研究评估了有监督的剧烈运动作为抑郁症女性戒烟干预措施的潜在作用。
招募了30名有中度至重度抑郁症状的成年女性，并将她们随机分配，分别进行为期12周、每周三次、在基督教青年会环境中进行的有监督的剧烈强度运动（运动组；n = 15）或健康教育（健康教育组；n = 15）。所有参与者都接受了行为戒烟咨询和尼古丁贴片治疗。在基线、治疗12周结束时以及目标戒烟日期后的6个月进行面对面评估。主要终点是运动依从性（参加36次课程的比例）和在第12周经生化确认的7天点患病率戒烟情况。探讨了炎症生物标志物在治疗组之间以及在第12周吸烟女性和戒烟女性之间的差异。
两组的治疗依从性都很高（运动组为72%，健康教育组为66%；p = 0.55）。运动组在第12周的戒烟率高于健康教育组（11/15 [73%] 对5/15 [33%]；p = 0.028），但在6个月随访时没有出现显著差异。在第12周，吸烟者的白细胞介素-6水平比戒烟者升高得更多（p = 0.040）。
有监督地进行剧烈强度运动是可行的，并且能提高抑郁女性吸烟者的短期戒烟率。需要评估在这一人群中加强长期运动依从性和戒烟的创新且具成本效益的策略。炎症生物标志物可在未来研究中作为治疗效果的调节因子进行检测。
这项初步研究发现，有监督的剧烈强度运动是可行的，并且能提高抑郁女性吸烟者的短期戒烟率。该研究填补了该领域的一个重要空白。尽管数十年来一直在研究运动干预对戒烟的作用，但针对抑郁吸烟者或患有精神疾病合并症的吸烟者的研究很少。一个新发现是，与未吸烟的女性相比，干预结束时吸烟的女性中一种促炎生物标志物的水平有所升高。
