Hajiaghamohammadi Ali Akbar, Zargar Ali, Oveisi Sonia, Samimi Rasoul, Reisian Sedigheh
Qazvin University of Medical Sciences, Velayat Clinical Research Development Unit, Department of Internal Medicine, Qazvin, Iran.
Qazvin University of Medical Sciences, Metabolic Diseases Research Center, Qazvin, Iran.
Braz J Infect Dis. 2016 Nov-Dec;20(6):534-538. doi: 10.1016/j.bjid.2016.07.015. Epub 2016 Sep 8.
The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen.
In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups: control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks. H. pylori eradication was assessed six weeks after therapy. Data was analyzed by chi-square and t-test with SPSS 16 software.
Mean ages and SD were 38.8±10.9 and 40.1±10.4 for the study and control groups, respectively, statistically similar. Peptic ulcer was found in 30% of both groups. Response to treatment was 83.3% and 62.5% in the study and control groups, respectively. This difference was statistically significant.
Addition of licorice to the triple clarithromycin-based regimen increases H. pylori eradication, especially in the presence of peptic ulcer disease.
本研究旨在评估与基于克拉霉素的标准三联疗法相比，甘草对患有消化不良伴消化性溃疡病（PUD）或非溃疡性消化不良（NUD）患者根除幽门螺杆菌的效果。
在这项随机对照临床试验中，纳入120例快速尿素酶试验呈阳性的患者，并将其分为两个治疗组：对照组接受基于克拉霉素的三联疗法，研究组在基于克拉霉素的疗法基础上额外服用甘草，为期两周。治疗六周后评估幽门螺杆菌的根除情况。使用SPSS 16软件通过卡方检验和t检验分析数据。
研究组和对照组的平均年龄及标准差分别为38.8±10.9和40.1±10.4，在统计学上相似。两组中均有30%的患者患有消化性溃疡。研究组和对照组的治疗有效率分别为83.3%和62.5%。这种差异具有统计学意义。
在基于克拉霉素的三联疗法中添加甘草可提高幽门螺杆菌的根除率，尤其是在存在消化性溃疡病的情况下。
