多酚化合物对根除的影响：系统评价与荟萃分析。
Effect of polyphenol compounds on eradication: a systematic review with meta-analysis.
机构信息
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Affiliated hospital of Chengdu university of traditional Chinese medicine, Chengdu, Sichuan, China.
出版信息
BMJ Open. 2023 Jan 5;13(1):e062932. doi: 10.1136/bmjopen-2022-062932.
OBJECTIVES
Polyphenol compounds are classified as organic compounds with phenolic units exhibiting a variety of biological functions. This meta-analysis aims to assess the efficacy and safety of polyphenol compounds (curcumin, cranberry, garlic, liquorice and broccoli) in eradicating .
DESIGN
Systematic review and meta-analysis.
METHODS
Literature searches were conducted on PubMed, Embase, The Cochrane Library, Web of Science, Medline, Chinese National Knowledge Infrastructure database, Chinese Scientific Journal Database and Wan Fang database from inception to January 2022. All randomised controlled trials comparing polyphenol compounds with the placebo or used as an adjunct treatment are included in this meta-analysis.The treatment effect for dichotomous outcomes was assessed using risk ratio (RR), while for continuous outcomes, mean differences both with 95% CIs, were used. Subgroup analyses were carried out for different treatment schemes and polyphenol compound species.
RESULTS
12 trials were included in the meta-analysis. The total eradication rate of in the polyphenol compounds group was higher than in the group without polyphenol compounds. Statistical significance was also observed (RR 1.19, 95% CI 1.03 to 1.38, p=0.02). The most frequent adverse effects of polyphenol compounds included diarrhoea, headache and vomiting. However, there were no differences regarding side effects between the two groups (RR 1.47, 95% CI 0.83 to 2.58, p=0.18). In subgroup analyses, the eradication rate regimens with polyphenols therapy was superior to that of regimens without polyphenols therapy in the polyphenols versus placebo subgroup (RR 4.23, 95% CI 1.38 to 12.95, p=0.01), polyphenols plus triple therapy versus triple therapy subgroup (RR 1.11, 95% CI 1.01 to 1.22, p=0.03).
CONCLUSION
Polyphenol compounds can improve eradication rates. Polyphenol compounds plus standard triple therapy can significantly improve the eradication. However, no evidence of a higher incidence of side effects could be found.
PROSPERO REGISTRATION NUMBER
CRD42022307477.
目的
多酚化合物被归类为具有酚单元的有机化合物，具有多种生物功能。本荟萃分析旨在评估多酚化合物（姜黄素、越橘、大蒜、甘草和西兰花）在根除中的疗效和安全性。
设计
系统评价和荟萃分析。
方法
从建库到 2022 年 1 月，在 PubMed、Embase、The Cochrane Library、Web of Science、Medline、中国知网数据库、中国科学期刊数据库和万方数据库上进行文献检索，纳入比较多酚化合物与安慰剂或作为辅助治疗的随机对照试验。二分类结局的治疗效果采用风险比（RR）评估，连续结局采用均数差值及 95%置信区间（CI）表示。进行了不同治疗方案和多酚化合物种类的亚组分析。
结果
荟萃分析纳入 12 项试验。多酚化合物组的总根除率高于无多酚化合物组，差异有统计学意义（RR 1.19，95%CI 1.03 至 1.38，p=0.02）。多酚化合物最常见的不良反应包括腹泻、头痛和呕吐。然而，两组之间的不良反应无差异（RR 1.47，95%CI 0.83 至 2.58，p=0.18）。在亚组分析中，多酚化合物治疗方案的根除率优于无多酚化合物治疗方案的根除率（多酚化合物与安慰剂亚组 RR 4.23，95%CI 1.38 至 12.95，p=0.01），多酚化合物加三联疗法与三联疗法亚组 RR 1.11，95%CI 1.01 至 1.22，p=0.03）。
结论
多酚化合物可以提高的根除率。多酚化合物加标准三联疗法可显著提高根除率。然而，未发现不良反应发生率更高的证据。
PROSPERO 注册号：CRD42022307477。
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