Maiorino Maria Ida, Bellastella Giuseppe, Caputo Mariangela, Castaldo Filomena, Improta Maria Rosaria, Giugliano Dario, Esposito Katherine
Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy.
Diabetes Unit, Department of Clinical and Experimental Medicine, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy.
J Diabetes Complications. 2016 Nov-Dec;30(8):1519-1524. doi: 10.1016/j.jdiacomp.2016.08.007. Epub 2016 Aug 12.
To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly diagnosed type 2 diabetes.
In a randomized clinical trial, with a total follow-up of 8.1years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n=108) or a low-fat diet (n=107). The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women.
There was no difference in baseline sexual function in men (n=54 vs 52) or women (n=54 vs 55) randomized to Mediterranean diet or low-fat diet, respectively (P=0.287, P=0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P=0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted erectile dysfunction in men but not female sexual dysfunction in women.
Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes.
评估地中海饮食与低脂饮食相比，对新诊断的2型糖尿病患者性功能的长期影响。
在一项随机临床试验中，共随访8.1年，将215例新诊断的2型糖尿病男性和女性患者分为地中海饮食组（n = 108）或低脂饮食组（n = 107）。主要结局指标为糖尿病男性的勃起功能（IIEF）变化和糖尿病女性的性功能（FSFI）变化。
随机分配到地中海饮食组或低脂饮食组的男性（n = 54 vs 52）或女性（n = 54 vs 55）的基线性功能无差异（P = 0.287，P = 0.815）。在整个随访期间，地中海饮食组主要结局的变化明显低于低脂组：地中海饮食组的IIEF和FSFI下降明显较小（分别为1.22和1.18，P = 0.024和0.019）。基线C反应蛋白水平可预测男性勃起功能障碍，但不能预测女性性功能障碍。
在新诊断的2型糖尿病患者中，地中海饮食可减缓两性性功能随时间的恶化。
