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亚洲印度人中性粒细胞与淋巴细胞比值与代谢综合征及其组分的关联（CURES-143研究）

Association of neutrophil-lymphocyte ratio with metabolic syndrome and its components in Asian Indians (CURES-143).

作者信息

Surendar Jayagopi, Indulekha Karunakaran, Mohan Viswanathan, Pradeepa Rajendra

机构信息

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention & Control, Gopalapuram, Chennai, India.

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention & Control, Gopalapuram, Chennai, India.

出版信息

J Diabetes Complications. 2016 Nov-Dec;30(8):1525-1529. doi: 10.1016/j.jdiacomp.2016.08.006. Epub 2016 Aug 12.

DOI:10.1016/j.jdiacomp.2016.08.006
PMID:27615666
Abstract

BACKGROUND

Metabolic syndrome (MS) is the state of chronic low grade inflammation. This study looks at the relationship of neutrophil-lymphocyte ratio (NLR) in subjects with and without MS in Asian Indians.

METHODS

Study subjects (n=754) were recruited from the Chennai Urban Rural Epidemiology Study. MS was defined using the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III criteria modified for waist according to World Health Organization Asia Pacific guidelines. A complete hemogram was done in all subjects using a five-part hematology analyzer (model SF-3000; Sysmex, Kobe, Japan). The NLR was calculated as the ratio between counts for neutrophils and total lymphocytes in subjects with (n=422) and without (n332) MS and correlated with number of metabolic abnormalities in those with MS.

RESULTS

Subjects with five metabolic abnormalities had the highest NLR, and with decreasing number of metabolic abnormalities, the NLR decreased linearly (p for trend <0.001). Logistic regression analysis revealed that even after adjusting for age, gender and body mass index, MS was strongly associated with NLR (p<0.001).

CONCLUSION

Among Asian Indians, NLR is correlated with MS and also with the number of metabolic abnormalities.

摘要

背景

代谢综合征（MS）是一种慢性低度炎症状态。本研究旨在探讨亚洲印度人群中患与未患MS个体的中性粒细胞与淋巴细胞比值（NLR）之间的关系。

方法

研究对象（n = 754）来自金奈城乡流行病学研究。MS采用根据世界卫生组织亚太地区指南对腰围进行修正的美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP-ATP III）标准进行定义。所有研究对象均使用五分类血液分析仪（型号SF-3000；日本神户Sysmex公司）进行全血细胞计数。计算患MS（n = 422）和未患MS（n = 332）个体的中性粒细胞与淋巴细胞比值，并将其与患MS个体的代谢异常数量进行关联分析。

结果

具有五项代谢异常的个体NLR最高，随着代谢异常数量的减少，NLR呈线性下降（趋势p < 0.001）。逻辑回归分析显示，即使在调整年龄、性别和体重指数后，MS仍与NLR密切相关（p < 0.001）。

结论

在亚洲印度人群中，NLR与MS以及代谢异常数量相关。

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