Steinmetz Jean-Paul, Vögele Claus, Theisen-Flies Christiane, Federspiel Carine, Sütterlin Stefan
Department of Research and Development, ZithaSenior; Centre for Memory and Mobility, ZithaSenior.
Institute for Health and Behaviour, Integrative Research Unit on Social and Individual Development (INSIDE), University of Luxembourg, Luxembourg; Research Group Health Psychology, University of Leuven, Leuven, Belgium.
Psychol Res Behav Manag. 2016 Aug 23;9:219-35. doi: 10.2147/PRBM.S108322. eCollection 2016.
The reliable measurement of quality of life (QoL) presents a challenge in individuals with alcohol-related brain damage. This study investigated vagally mediated heart rate variability (vmHRV) as a physiological predictor of QoL. Self- and proxy ratings of QoL and dysexecutive symptoms were collected once, while vmHRV was repeatedly assessed over a 3-week period at weekly intervals in a sample of nine alcohol-related brain damaged patients. We provide robustness checks, bootstrapped correlations with confidence intervals, and standard errors for mean scores. We observed low to very low heart rate variability scores in our patients in comparison to norm values found in healthy populations. Proxy ratings of the QoL scale "subjective physical and mental performance" and everyday executive dysfunctions were strongly related to vmHRV. Better proxy-rated QoL and fewer dysexecutive symptoms were observed in those patients with higher vmHRV. Overall, patients showed low parasympathetic activation favoring the occurrence of dysfunctional emotion regulation strategies.
对酒精相关脑损伤个体的生活质量（QoL）进行可靠测量是一项挑战。本研究调查了迷走神经介导的心率变异性（vmHRV）作为生活质量的生理预测指标。生活质量和执行功能障碍症状的自评及他人评定仅收集一次，而在9名酒精相关脑损伤患者的样本中，每周对vmHRV进行重复评估，为期3周。我们提供了稳健性检验、带有置信区间的自抽样相关性以及平均分数的标准误差。与健康人群的正常数值相比，我们观察到患者的心率变异性得分较低至极低。生活质量量表“主观身心表现”的他人评定以及日常执行功能障碍与vmHRV密切相关。在vmHRV较高的患者中，观察到他人评定的生活质量更好且执行功能障碍症状更少。总体而言，患者的副交感神经激活水平较低，这有利于功能失调性情绪调节策略的出现。
