巴西2015年疫情中新生儿小头畸形病例脑表型的放射学特征
Radiological Characterization of Cerebral Phenotype in Newborn Microcephaly Cases from 2015 Outbreak in Brazil.
作者信息
Ramalho Rocha Yuri Raoni, Cavalcanti Costa José Ricardo, Almeida Costa Pericles, Maia Gessica, Vasconcelos Rafael de Medeiros, Ramos Tejo Cynthia, Martins Batista Rafaella, Lima Neto Manoel, Martins de Lima Gustavo Graco, Negromonte Francisco, Borba Marcelle, Bezerra Jeronimo Selma Maria, Sequerra Eduardo Bouth, Moreira Neto Manuel
机构信息
Radiologia e Diagnóstico por Imagem, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Institute of Science and Technology of Tropical Diseases, Brazil.
出版信息
PLoS Curr. 2016 Jun 8;8:ecurrents.outbreaks.e854dbf51b8075431a05b39042c00244. doi: 10.1371/currents.outbreaks.e854dbf51b8075431a05b39042c00244.
INTRODUCTION
Brazil is facing, since October of 2015, an outbreak of microcephalic fetuses. This outbreak is correlated with the beginning of circulation of Zika virus (ZIKV) in the country. Although it is clear that the size of the head is diminished in these fetuses, the brain phenotype associated with these malformations is unknown.
METHODS
We collected computed tomography images of the microcephaly cases from the region of Natal, Rio Grande do Norte, from September 2015 to February 2016.
FINDINGS
The microcephalies derived from the current outbreak are associated with intracerebral calcifications, malformation of the ventricular system, migratory disorders in the telencephalon and, in a lower frequency, malformation of the cerebellum and brainstem.
DISCUSSION
The characteristics described herein are not usually found in other types of microcephaly. We suggest that this work can be used as a guideline to identify microcephaly cases associated to the current outbreak.
引言
自2015年10月以来，巴西面临小头畸形胎儿的疫情爆发。此次疫情爆发与寨卡病毒（ZIKV）在该国开始传播有关。尽管很明显这些胎儿的头部尺寸减小，但与这些畸形相关的脑表型尚不清楚。
方法
我们收集了2015年9月至2016年2月来自北里奥格兰德州纳塔尔地区小头畸形病例的计算机断层扫描图像。
研究结果
当前疫情爆发导致的小头畸形与脑内钙化、脑室系统畸形、端脑迁移障碍以及较低频率的小脑和脑干畸形有关。
讨论
本文所述特征通常在其他类型的小头畸形中未发现。我们建议这项工作可作为识别与当前疫情相关的小头畸形病例的指导。
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