聚羟基烷酸酯/碳纳米管纳米复合材料：用于神经应用的柔性导电弹性体。
Polyhydroxyalkanoate/carbon nanotube nanocomposites: flexible electrically conducting elastomers for neural applications.
机构信息
CÚRAM - Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland.
Department of Biomedical Engineering, National University of Ireland, Galway, Ireland.
出版信息
Nanomedicine (Lond). 2016 Oct;11(19):2547-63. doi: 10.2217/nnm-2016-0075. Epub 2016 Sep 13.
AIM
Medium chain length-polyhydroxyalkanoate/multi-walled carbon nanotube (MWCNTs) nanocomposites with a range of mechanical and electrochemical properties were fabricated via assisted dispersion and solvent casting, and their suitability as neural interface biomaterials was investigated.
MATERIALS & METHODS: Mechanical and electrical properties of medium chain length-polyhydroxyalkanoate/MWCNTs nanocomposite films were evaluated by tensile test and electrical impedance spectroscopy, respectively. Primary rat mesencephalic cells were seeded on the composites and quantitative immunostaining of relevant neural biomarkers, and electrical stimulation studies were performed.
RESULTS
Incorporation of MWCNTs to the polymeric matrix modulated the mechanical and electrical properties of resulting composites, and promoted differential cell viability, morphology and function as a function of MWCNT concentration.
CONCLUSION
This study demonstrates the feasibility of a green thermoplastic MWCNTs nanocomposite for potential use in neural interfacing applications.
目的
通过辅助分散和溶剂浇铸制备具有一系列机械和电化学性能的中链聚羟基烷酸酯/多壁碳纳米管（MWCNTs）纳米复合材料，并研究其作为神经界面生物材料的适用性。
材料与方法
通过拉伸试验和交流阻抗谱分别评估中链聚羟基烷酸酯/MWCNTs 纳米复合材料薄膜的机械和电学性能。将原代大鼠中脑细胞接种到复合材料上，并进行相关神经生物标志物的定量免疫染色和电刺激研究。
结果
MWCNTs 的掺入调节了所得复合材料的机械和电学性能，并促进了细胞活力、形态和功能的差异，这取决于 MWCNT 的浓度。
结论
本研究证明了绿色热塑性 MWCNTs 纳米复合材料在神经接口应用中的潜在可行性。
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