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上皮-间质转化在肝癌中的新作用。

Emerging role of epithelial-mesenchymal transition in hepatic cancer.

作者信息

Yoshida Go J

机构信息

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo, 102-0083, Japan.

出版信息

J Exp Clin Cancer Res. 2016 Sep 13;35(1):141. doi: 10.1186/s13046-016-0419-7.

DOI:10.1186/s13046-016-0419-7
PMID:27619936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5020508/
Abstract

Accumulating evidence suggests that the phenomenon of epithelial-mesenchymal-transition (EMT) plays a fundamental role in the tumor development. Several research articles have been published from Journal of Experimental and Clinical Cancer Research (JECCR) which have investigated into the molecular machineries underlying the importance of EMT for hepatic cancer. Given those recent publications by JECCR, this commentary focuses on the pathological significance of EMT for liver tumor.

摘要

越来越多的证据表明，上皮-间质转化（EMT）现象在肿瘤发展中起着至关重要的作用。《实验与临床癌症研究杂志》（JECCR）发表了几篇研究文章，探讨了EMT对肝癌重要性的分子机制。鉴于JECCR最近发表的这些文章，本评论聚焦于EMT对肝肿瘤的病理意义。

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本文引用的文献

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Nestin overexpression in hepatocellular carcinoma associates with epithelial-mesenchymal transition and chemoresistance.巢蛋白在肝细胞癌中的过表达与上皮-间质转化及化疗耐药相关。
J Exp Clin Cancer Res. 2016 Jul 13;35(1):111. doi: 10.1186/s13046-016-0387-y.
2
Overexpression of CTNND1 in hepatocellular carcinoma promotes carcinous characters through activation of Wnt/β-catenin signaling.CTNND1在肝细胞癌中的过表达通过激活Wnt/β-连环蛋白信号传导促进癌性特征。
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DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1.DDR2通过激活ERK信号通路和稳定SNAIL1促进肝细胞癌的侵袭和转移。
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Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.短尾相关转录因子的过表达通过诱导肝细胞癌的上皮-间质转化促进肿瘤转移。
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