Niu Zhaozhuo, Chan Vincent, Mesana Thierry, Ruel Marc
University of Ottawa Heart Institute, Ottawa, Canada;; Qingdao Municipal Hospital, Qingdao 266011, China.
University of Ottawa Heart Institute, Ottawa, Canada ;
J Thorac Dis. 2016 Aug;8(8):E827-8. doi: 10.21037/jtd.2016.07.58.
The Framingham Heart Study group has described the non-diagnostic variants may evolve into mitral valve prolapse over time. These non-diagnostic variants include minimal systolic displacement, and abnormal anterior coaptation which is measured on surface echocardiography. Computed tomography and cardiac magnetic resonance imaging are evolving and can assess the degree of mitral regurgitation (MR); imaging techniques aside, genetic and proteomic detection of mitral prolapse is also evolving. However, the genetic basis for mitral prolapse is complex and likely involves multiple genetic loci. The same is also true for work determining possible biomarkers associated with mitral prolapse. The present study may be useful in counseling patients with a family history of mitral prolapse. Registry data is therefore of paramount importance in providing unbiased insight into this common disease.
弗明汉心脏研究小组描述了非诊断性变异可能随时间演变为二尖瓣脱垂。这些非诊断性变异包括最小收缩期移位，以及通过体表超声心动图测量的异常前叶对合。计算机断层扫描和心脏磁共振成像技术不断发展，能够评估二尖瓣反流（MR）的程度；除了成像技术外，二尖瓣脱垂的基因和蛋白质组检测也在不断发展。然而，二尖瓣脱垂的遗传基础很复杂，可能涉及多个基因位点。确定与二尖瓣脱垂相关的可能生物标志物的研究工作也是如此。本研究可能有助于为有二尖瓣脱垂家族史的患者提供咨询。因此，登记数据对于公正地了解这种常见疾病至关重要。
