多种炎性小体的其他功能。
Alternative functions for the multifarious inflammasome.
作者信息
Martel Jan, Lai Hsin-Chih, Ko Yun-Fei, Young John D, Ojcius David M
机构信息
Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Laboratory of Nanomaterials, Chang Gung University, Taoyuan, Taiwan.
Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center of Bacterial Pathogenesis, Chang Gung University, Taoyuan, Taiwan; Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Research Center for Industry of Human Ecology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Graduate Institute of Health Industry and Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
出版信息
Biomed J. 2016 Jun;39(3):183-7. doi: 10.1016/j.bj.2016.06.001. Epub 2016 Aug 23.
The inflammasome has been mainly studied in innate immune cells in which it senses microbes and cellular damage, and induces secretion of pro-inflammatory cytokines. This process induces an inflammatory response that is critical for the resolution of infections and repair of tissue damage following injury. Recent studies indicate that inflammasome complex formation also participates in many other cellular and physiological processes beyond modulation of inflammation, such as autophagy, metabolism, eicosanoids production, and phagosome maturation.
炎性小体主要在先天性免疫细胞中得到研究，在这些细胞中它可感知微生物和细胞损伤，并诱导促炎细胞因子的分泌。这一过程引发的炎症反应对于感染的消退和损伤后组织损伤的修复至关重要。最近的研究表明，炎性小体复合物的形成还参与了许多其他细胞和生理过程，而不仅仅是炎症调节，如自噬、代谢、类花生酸生成和吞噬体成熟。
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