Collins Brendan, Williams Jeremy Z, Karu Heather, Hodde Jason P, Martin Victoria A, Gurtner Geoffrey C
Department of Surgery, Mercy Weinberg Women's Hospital, Baltimore, Md.; Park Meadows Cosmetic Surgery, Lone Tree, Colo.; Department of Surgery, Sanford School of Medicine, Sioux Falls, S.Dak.; Cook Biotech Incorporated, West Lafayette, Ind. Department of Surgery, Stanford University School of Medicine, Stanford, Calif.; and Cook Research Incorporated, West Lafayette, Ind.
Plast Reconstr Surg Glob Open. 2016 Aug 9;4(8):e832. doi: 10.1097/GOX.0000000000000846. eCollection 2016 Aug.
Nipple reconstruction is the last stage in cosmetic reconstruction of the breast after mastectomy, but no method produces reliable and consistent aesthetic results. This study examined the use of the Biodesign Nipple Reconstruction Cylinder (NRC) during reconstruction of the nipple after mastectomy.
Patients with a history of breast cancer and mastectomy desiring nipple reconstruction were invited to participate. After obtaining consent, unilateral or bilateral nipple reconstruction was performed. Skin flaps were raised, the NRC was placed beneath the flaps as a stent, and the site was protected for up to 4 weeks with a nipple shield. Nipple projection was measured for 12 months after surgery. Patient satisfaction was measured and adverse events were recorded. Follow-up examinations were performed at 1 week, and then at 1, 3, 6, and 12 months after surgery.
Eighty-two nipple reconstructions were performed in 50 patients. Related postoperative adverse events were minor, but reported in 8 reconstructions (9.8%) representing 7 patients (14.0%). Average projection at 6 and 12 months was 4.1 ± 1.6 mm and 3.8 ± 1.5 mm, respectively, compared with 10.5 ± 2.2 mm 1 week after surgery. Of patients completing the satisfaction questionnaire at 12 months, 70/75 (93.3%) of reconstructions were rated "pleased" or "very pleased" with the overall outcome. Overall, 45/46 (97.8%) patients would recommend nipple reconstruction to other women.
The Biodesign NRC offers a safe alternative to nipple reconstruction, resulting in stable projection and a high level of patient satisfaction for 12 months after placement.
乳头重建是乳房切除术后乳房美容重建的最后阶段，但尚无方法能产生可靠且一致的美学效果。本研究探讨了在乳房切除术后乳头重建过程中使用生物设计乳头重建圆柱体（NRC）的情况。
邀请有乳腺癌病史且接受过乳房切除术并希望进行乳头重建的患者参与。获得同意后，进行单侧或双侧乳头重建。掀起皮瓣，将NRC置于皮瓣下方作为支架，并用乳头防护罩对该部位进行长达4周的保护。术后12个月测量乳头突出度。测量患者满意度并记录不良事件。术后1周进行随访检查，然后在术后1、3、6和12个月进行随访检查。
50例患者共进行了82次乳头重建。相关术后不良事件较轻，但在8次重建（9.8%）中出现，涉及7例患者（14.0%）。术后6个月和12个月的平均突出度分别为4.1±1.6毫米和3.8±1.5毫米，而术后1周为10.5±2.2毫米。在12个月完成满意度问卷的患者中，70/75（93.3%）的重建对总体结果评为“满意”或“非常满意”。总体而言，45/46（97.8%）的患者会向其他女性推荐乳头重建。
生物设计NRC为乳头重建提供了一种安全的替代方法，在放置后12个月内可实现稳定的突出度并获得较高的患者满意度。
