Hodde Jason
Cook Biotech Incorporated, West Lafayette, Indiana 47906, USA.
ANZ J Surg. 2006 Dec;76(12):1096-100. doi: 10.1111/j.1445-2197.2006.03948.x.
The extracellular matrix (ECM) directs all phases of healing following trauma or disease and is therefore a natural source of prosthetic mesh material that can be used strategically to induce the repair and restoration of soft tissues following surgery. Biomaterials such as Surgisis (Cook Biotech Incorporated, West Lafayette, IN, USA), which are derived from natural ECM, provide the extracellular components necessary to direct the healing response, allow for the proliferation of new, healthy tissue and restore tissue integrity to the damaged site. The 3-D organization of these extracellular components distinguishes the Surgisis mesh from synthetic materials and is associated with constructive tissue remodelling instead of scar tissue. Common features of this ECM-assisted tissue remodelling include angiogenesis, recruitment of circulating progenitor cells and constructive remodelling of damaged tissue structures. The tissue response to this biologic mesh is discussed in the context of recent reports on clinical hernia repair.
细胞外基质（ECM）指导创伤或疾病后的所有愈合阶段，因此是一种天然的人工合成网片材料来源，可被战略性地用于诱导手术后软组织的修复和恢复。诸如Surgisis（美国印第安纳州西拉斐特市库克生物技术公司）等源自天然ECM的生物材料，提供了引导愈合反应所需的细胞外成分，允许新的健康组织增殖，并将组织完整性恢复到受损部位。这些细胞外成分的三维结构使Surgisis网片有别于合成材料，并与建设性的组织重塑而非瘢痕组织相关。这种ECM辅助的组织重塑的共同特征包括血管生成、循环祖细胞的募集以及受损组织结构的建设性重塑。本文将结合近期关于临床疝修补的报道来讨论组织对这种生物网片的反应。
