Beaudoin A R, Bégin M E, Ells G, St-Jean P, Laforest L, Proulx J, Vachereau A
Centre de Recherche sur les Mécanismes de Sécrétion, Faculté des Sciences, Université de Sherbrooke, Québec, Canada.
Pancreas. 1989;4(4):418-22. doi: 10.1097/00006676-198908000-00004.
A possible influence of the type of dietary lipids on the pancreas exocrine function was tested on rats. For this purpose, four groups of rats were fed on different diets comprising 5% of different types of lipids: fish oil, evening primose oil, hydrogenated beef tallow, and a mixture of fish oil and evening primose oil. After a 6 week feeding period, the secretory activity of the pancreas was measured. Under resting conditions, rats fed hydrogenated beef tallow release different proportions of amylase, lipase, and serine proteases as compared to rats fed unsaturated lipids. In stimulated conditions, there was no significant difference in the relative proportions of enzymes secreted by the pancreas among the different groups of rats but the secretory response to cerulein stimulation from rats fed saturated lipids was increased by more than 40%. These results demonstrate that the type of dietary lipids exerts a major influence on the secretory activity of the pancreas.
在大鼠身上测试了膳食脂质类型对胰腺外分泌功能的可能影响。为此，将四组大鼠分别喂食不同的饮食，这些饮食含有5%的不同类型脂质：鱼油、月见草油、氢化牛脂，以及鱼油和月见草油的混合物。在6周的喂养期后，测量胰腺的分泌活性。在静息条件下，与喂食不饱和脂质的大鼠相比，喂食氢化牛脂的大鼠释放出不同比例的淀粉酶、脂肪酶和丝氨酸蛋白酶。在刺激条件下，不同组大鼠胰腺分泌的酶的相对比例没有显著差异，但喂食饱和脂质的大鼠对雨蛙肽刺激的分泌反应增加了40%以上。这些结果表明，膳食脂质类型对胰腺的分泌活性有重大影响。
