Vaughn D M, Swaim S F, Milton J L
Department of Small Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, Alabama 36849.
Prostaglandins Leukot Essent Fatty Acids. 1989 Jul;37(1):45-50. doi: 10.1016/0952-3278(89)90185-3.
Arachidonic acid metabolites have been implicated as mediators of progressive dermal ischemia. Decubitus ulcer formation results from chronic mechanical pressure on the skin which results in a diminished blood supply to the skin and underlying tissues. To evaluate the role of thromboxanes in pressure wounds, we measured TxB2, a stable metabolite of TxA2, in spontaneously occurring pressure wounds on Greyhound dogs. In pressure wounds in which the skin was showing early signs of pressure necrosis but was still intact, elevated TxB2 concentrations were found in healthy appearing tissues immediately adjacent to the pressure wounds, in the inner edge of the wounds, and in the center of the wounds. Significantly greater TxB2 concentrations (P less than 0.05) were found in the center of the intact wounds versus the TxB2 concentrations in the inner edge of the wounds or in healthy appearing tissues adjacent to the wounds. In pressure wounds in which the center of the wound had ulcerated or had an eschar, elevated TxB2 concentrations were found in tissues in the inner edge of the wounds and in healthy appearing tissues immediately adjacent to the pressure wounds. These results demonstrate the occurrence of elevated thromboxane concentrations in and around spontaneously occurring pressure wounds.
花生四烯酸代谢产物被认为是进行性皮肤缺血的介质。褥疮的形成是由于皮肤长期受到机械压力，导致皮肤和皮下组织的血液供应减少。为了评估血栓素在压力性伤口中的作用，我们测量了灵缇犬自发性压力性伤口中血栓素A2（TxA2）的稳定代谢产物TxB2。在皮肤出现早期压力性坏死迹象但仍完整的压力性伤口中，在紧邻压力性伤口的外观正常的组织、伤口内边缘以及伤口中心发现TxB2浓度升高。与伤口内边缘或紧邻伤口的外观正常组织中的TxB2浓度相比，完整伤口中心的TxB2浓度显著更高（P小于0.05）。在伤口中心已发生溃疡或有焦痂的压力性伤口中，在伤口内边缘的组织以及紧邻压力性伤口的外观正常组织中发现TxB2浓度升高。这些结果表明，在自发性压力性伤口及其周围存在血栓素浓度升高的情况。
