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Reelin调节新生颗粒细胞树突棘的成熟、突触形成和胶质细胞包裹。

Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells.

作者信息

Bosch Carles, Masachs Nuria, Exposito-Alonso David, Martínez Albert, Teixeira Cátia M, Fernaud Isabel, Pujadas Lluís, Ulloa Fausto, Comella Joan X, DeFelipe Javier, Merchán-Pérez Angel, Soriano Eduardo

机构信息

Developmental Neurobiology and Regeneration Unit, Department of Cell Biology, Parc Científic de Barcelona and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid 28031, Spain.

出版信息

Cereb Cortex. 2016 Oct 17;26(11):4282-4298. doi: 10.1093/cercor/bhw216.

DOI:10.1093/cercor/bhw216
PMID:27624722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5066826/
Abstract

The extracellular protein Reelin has an important role in neurological diseases, including epilepsy, Alzheimer's disease and psychiatric diseases, targeting hippocampal circuits. Here we address the role of Reelin in the development of synaptic contacts in adult-generated granule cells (GCs), a neuronal population that is crucial for learning and memory and implicated in neurological and psychiatric diseases. We found that the Reelin pathway controls the shapes, sizes, and types of dendritic spines, the complexity of multisynaptic innervations and the degree of the perisynaptic astroglial ensheathment that controls synaptic homeostasis. These findings show a pivotal role of Reelin in GC synaptogenesis and provide a foundation for structural circuit alterations caused by Reelin deregulation that may occur in neurological and psychiatric disorders.

摘要

细胞外蛋白Reelin在包括癫痫、阿尔茨海默病和精神疾病在内的神经疾病中发挥着重要作用，其作用靶点为海马回路。在此，我们探讨Reelin在成年生成的颗粒细胞（GCs）突触联系发育中的作用，GCs是一类对学习和记忆至关重要且与神经和精神疾病相关的神经元群体。我们发现，Reelin信号通路控制树突棘的形状、大小和类型、多突触神经支配的复杂性以及控制突触稳态的突触周围星形胶质细胞包被程度。这些发现表明Reelin在GCs突触形成中起关键作用，并为神经和精神疾病中可能因Reelin失调而导致的结构回路改变提供了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/3af1357c199c/bhw216f09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/3abc6f6fa3ae/bhw216f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/cd52c7c6a98b/bhw216f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/444092e9676d/bhw216f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/2c2778e724f0/bhw216f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/222eaa7af49e/bhw216f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/41cb657fba37/bhw216f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/06548b508805/bhw216f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/fe5672f3abe2/bhw216f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/3af1357c199c/bhw216f09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/3abc6f6fa3ae/bhw216f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/cd52c7c6a98b/bhw216f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/444092e9676d/bhw216f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/2c2778e724f0/bhw216f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/222eaa7af49e/bhw216f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/41cb657fba37/bhw216f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/06548b508805/bhw216f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/fe5672f3abe2/bhw216f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c88e/5066826/3af1357c199c/bhw216f09.jpg

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Lifetime development of behavioural phenotype in the house mouse (Mus musculus).
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