Amundsen Siri, Øvrebø Torunn G, Amble Netta Marie S, Poole Anne Christine, Nordeng Hedvig
Department of Laboratory Medicine, Division of Diagnostic Services, University Hospital of North Norway, PO Box 63, N-9038, Tromsø, Norway.
Medical Pharmacology and Toxicology Research Group, Department of Medical Biology, Faculty of Health Sciences, The Arctic University of Norway (UiT), Tromsø, Norway.
Eur J Clin Pharmacol. 2016 Dec;72(12):1525-1535. doi: 10.1007/s00228-016-2127-9. Epub 2016 Sep 13.
Migraine is highly prevalent among women of fertile age. The main objectives of this study were to describe the prevalence and patterns of use of antimigraine medications during pregnancy and breastfeeding and to identify maternal and migraine-related factors associated with medication use during pregnancy.
The study is a cross-sectional internet-based survey among pregnant women and new mothers with migraine conducted in Norway from October 1, 2013 to February 1, 2014. Descriptive statistics were used to explore patterns of medication use, and logistic regression analysis was performed to examine the association between maternal socio-demographic and migraine-related factors and use of antimigraine medications during pregnancy.
Of the total 401 respondents, 34.9 % were pregnant and 65.1 % had delivered within the last 18 months. The majority reported use of antimigraine medications during pregnancy (73.3 %) and postpartum (64.8 %), yet less than a third considered their migraine to be optimally treated during pregnancy (31.7 %) and the breastfeeding period (27.2 %). The patterns of medication use markedly changed during pregnancy and postpartum. Women with moderate or severe migraine were more likely to use antimigraine medications during pregnancy compared to women with mild migraine.
Despite the fact that antimigraine medications were commonly used, the majority of the women felt that their migraine was suboptimally treated during pregnancy and postpartum. There was a decline in the use of medicines in pregnancy and postpartum, and the patterns of use markedly changed. Efforts to improve treatment of women with migraine during pregnancy and breastfeeding should be undertaken.
偏头痛在育龄女性中极为普遍。本研究的主要目的是描述孕期和哺乳期抗偏头痛药物的使用 prevalence 和模式，并确定与孕期药物使用相关的母亲及偏头痛相关因素。
该研究是一项于 2013 年 10 月 1 日至 2014 年 2 月 1 日在挪威对患有偏头痛的孕妇和新妈妈进行的基于互联网的横断面调查。使用描述性统计来探究药物使用模式，并进行逻辑回归分析以检验母亲社会人口统计学和偏头痛相关因素与孕期抗偏头痛药物使用之间的关联。
在总共 401 名受访者中，34.9% 为孕妇，65.1% 在过去 18 个月内分娩。大多数人报告在孕期（73.3%）和产后（64.8%）使用抗偏头痛药物，但不到三分之一的人认为她们的偏头痛在孕期（31.7%）和哺乳期（27.2%）得到了最佳治疗。孕期和产后药物使用模式发生了显著变化。与轻度偏头痛女性相比，中度或重度偏头痛女性在孕期更有可能使用抗偏头痛药物。
尽管抗偏头痛药物被普遍使用，但大多数女性认为她们的偏头痛在孕期和产后治疗效果欠佳。孕期和产后药物使用有所下降且使用模式显著改变。应努力改善孕期和哺乳期偏头痛女性的治疗。
原文中“prevalence”未翻译，因为没有给出对应的中文释义，需根据上下文理解其含义，推测此处可能是指“患病率”之类的意思。
