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双侧同时性前部缺血性视神经病变，一种经直接作用抗病毒药物治愈的丙型肝炎肝外表现。

Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals.

作者信息

Prud'homme Sylvie, Nevens Frederik, Casteels Ingele

机构信息

Division of Ophthalmology, University Hospitals KU Leuven, Leuven, Belgium.

Division Liver and Biliopancreatic Disorders, University Hospitals KU Leuven, Leuven, Belgium.

出版信息

GMS Ophthalmol Cases. 2016 Apr 4;6:Doc05. doi: 10.3205/oc000042. eCollection 2016.

DOI:10.3205/oc000042
PMID:27625964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5015795/
Abstract

We report a patient with a bilateral optic anterior ischemic neuropathy as an extrahepatic complication of a chronic hepatitis C (HCV) infection. The patient presented with a bilateral visual acuity loss and bilateral optic disc oedema. The optic neuropathy was associated with a sudden increase in the viral HCV load after a recent liver transplantation. The stop of the calcineurin inhibitor had no effect on the course of the optic neuropathy. Visual improvement and normalization of HCV viraemia occurred after treatment with sofosbuvir and daclatasvir, which are direct acting antivirals.

摘要

我们报告了一例慢性丙型肝炎（HCV）感染的肝外并发症——双侧视神经前部缺血性神经病变患者。该患者出现双侧视力丧失和双侧视盘水肿。视神经病变与近期肝移植后HCV病毒载量突然增加有关。停用钙调神经磷酸酶抑制剂对视神经病变的病程没有影响。使用直接作用抗病毒药物索磷布韦和达卡他韦治疗后，患者视力改善且HCV病毒血症恢复正常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b124/5015795/79652bfb3b3c/OC-06-05-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b124/5015795/2a42a8a18916/OC-06-05-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b124/5015795/79652bfb3b3c/OC-06-05-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b124/5015795/2a42a8a18916/OC-06-05-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b124/5015795/79652bfb3b3c/OC-06-05-g-002.jpg

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本文引用的文献

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