Cagli Kumral, Tok Derya, Turak Osman, Gunertem Eren, Yayla Cagri, Lafci Gokhan, Ulas Mahmut Mustafa, Cagli Kerim
Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiology, Ankara, Turkey.
Turkiye Yuksek Ihtisas Training & Research Hospital, Department of Cardiovascular Surgery, Ankara, Turkey.
Biomark Med. 2016 Oct;10(10):1039-1047. doi: 10.2217/bmm-2016-0157. Epub 2016 Sep 14.
To determine the association of monocyte count-to-high-density lipoprotein (HDL)-cholesterol ratio, a recently emerged inflammatory marker, with abdominal aortic aneurysm (AAA) size.
PATIENTS & METHODS: A total of 120 asymptomatic AAA subjects (99 male, mean age: 67.1 ± 10.2 years) were enrolled into the study. All data were compared between patients with low and high admission monocyte/HDL ratio. Multivariate linear regression analysis was performed to study the relationship between different variables and AAA size.
Compared to patients with below-median monocyte/HDL ratio, aneurysm diameter was significantly higher in above-median monocyte/HDL ratio group (54.3 ± 10.6 mm vs 62.0 ± 12.4 mm, p < 0.001, respectively). Hypertension, coronary artery disease, monocyte/HDL ratio and C-reactive protein were independently associated with AAA diameter.
Monocyte/HDL ratio is independently associated with AAA size.
确定单核细胞计数与高密度脂蛋白（HDL）胆固醇比值（一种新出现的炎症标志物）与腹主动脉瘤（AAA）大小之间的关联。
共有120例无症状AAA患者（99例男性，平均年龄：67.1±10.2岁）纳入本研究。对入院时单核细胞/HDL比值低和高的患者的所有数据进行比较。进行多变量线性回归分析以研究不同变量与AAA大小之间的关系。
与单核细胞/HDL比值低于中位数的患者相比，单核细胞/HDL比值高于中位数的组中动脉瘤直径显著更高（分别为54.3±10.6毫米对62.0±12.4毫米，p<0.001）。高血压、冠状动脉疾病、单核细胞/HDL比值和C反应蛋白与AAA直径独立相关。
单核细胞/HDL比值与AAA大小独立相关。
