单核细胞/高密度脂蛋白胆固醇比值与二叶式主动脉瓣患者升主动脉扩张相关。
Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve.
机构信息
Department of Cardiology, Faculty of Medicine, Kocaeli University, Kocaeli/Turkey.
Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara/Turkey.
出版信息
Afr Health Sci. 2021 Mar;21(1):96-104. doi: 10.4314/ahs.v21i1.14.
BACKGROUND
The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve.
METHODS
The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups.
RESULTS
The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve.
CONCLUSION
We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve.
背景
单核细胞计数与高密度脂蛋白胆固醇比值（MHR）在心血管疾病中的重要性已在多项研究中得到证实。升主动脉扩张（AAD）是二叶式主动脉瓣患者的常见并发症。在这项研究中，我们旨在研究 MHR 与二叶式主动脉瓣患者主动脉扩张之间的关系。
方法
研究人群包括 347 名患有二叶式主动脉瓣的患者。169 名主动脉扩张（升主动脉直径≥4.0cm）患者和 178 名无主动脉扩张患者。对两组患者进行超声心动图和实验室检查，并进行比较。
结果
参与者的平均年龄为 44.7±15.4 岁，在无主动脉扩张组的平均升主动脉直径为 3.2±0.3cm，在主动脉扩张阳性组为 4.4±0.4cm。主动脉扩张患者的 MHR 显著升高。在二叶式主动脉瓣患者中，MHR 和尿酸水平与主动脉扩张的存在独立相关。
结论
我们发现二叶式主动脉瓣患者的 MHR 与主动脉扩张之间存在显著关系。
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