Rousseaud Audrey, Moriceau Stephanie, Ramos-Brossier Mariana, Oury Franck
Horm Mol Biol Clin Investig. 2016 Nov 1;28(2):69-83. doi: 10.1515/hmbci-2016-0030.
Reciprocal relationships between organs are essential to maintain whole body homeostasis. An exciting interplay between two apparently unrelated organs, the bone and the brain, has emerged recently. Indeed, it is now well established that the brain is a powerful regulator of skeletal homeostasis via a complex network of numerous players and pathways. In turn, bone via a bone-derived molecule, osteocalcin, appears as an important factor influencing the central nervous system by regulating brain development and several cognitive functions. In this paper we will discuss this complex and intimate relationship, as well as several pathologic conditions that may reinforce their potential interdependence.
器官之间的相互关系对于维持全身的内环境稳定至关重要。最近，在两个看似不相关的器官——骨骼和大脑之间，出现了一种令人兴奋的相互作用。事实上，现在已经充分证实，大脑通过一个由众多参与者和途径组成的复杂网络，是骨骼内环境稳定的强大调节者。反过来，骨骼通过一种源自骨骼的分子——骨钙素，似乎成为了一个影响中枢神经系统的重要因素，它可以调节大脑发育和多种认知功能。在本文中，我们将讨论这种复杂而密切的关系，以及可能加强它们潜在相互依存关系的几种病理状况。
