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下一代流行病学：利用实时核心基因组多位点序列分型来支持感染控制政策。

Next-Generation Epidemiology: Using Real-Time Core Genome Multilocus Sequence Typing To Support Infection Control Policy.

作者信息

Dekker John P, Frank Karen M

机构信息

Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.

Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA

出版信息

J Clin Microbiol. 2016 Dec;54(12):2850-2853. doi: 10.1128/JCM.01714-16. Epub 2016 Sep 14.

DOI:10.1128/JCM.01714-16
PMID:27629902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5121370/
Abstract

Multidrug-resistant bacteria are responsible for substantial morbidity and mortality worldwide. Tracking the nosocomial spread of resistant bacteria is critical to infection control. Mellmann et al. (J. Clin. Microbiol. 54:2874-2881, 2016, http://dx.doi.org/10.1128/JCM.00790-16) have described prospective whole-genome sequencing with core genome multilocus sequencing typing (cgMLST) analysis for real-time surveillance and have addressed the practical aspects of implementing this type of operation in the hospital setting.

摘要

多重耐药菌在全球范围内导致了大量的发病和死亡。追踪耐药菌在医院内的传播对于感染控制至关重要。Mellmann等人（《临床微生物学杂志》54:2874 - 2881, 2016, http://dx.doi.org/10.1128/JCM.00790 - 16）描述了采用核心基因组多位点测序分型（cgMLST）分析进行前瞻性全基因组测序以进行实时监测，并探讨了在医院环境中实施此类操作的实际问题。

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