• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Could Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction?

作者信息

LeWinter Martin M, Zile Michael R

机构信息

From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.); and RHJ Department of Veterans Affairs Medical Center and the Medical University of South Carolina, Charleston (M.R.Z.).

出版信息

Circulation. 2016 Oct 11;134(15):1100-1104. doi: 10.1161/CIRCULATIONAHA.116.023648. Epub 2016 Sep 14.

DOI:10.1161/CIRCULATIONAHA.116.023648
PMID:27630137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5069174/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f28c/5069174/370aaeb198ef/nihms815437f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f28c/5069174/370aaeb198ef/nihms815437f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f28c/5069174/370aaeb198ef/nihms815437f1.jpg

相似文献

1
Could Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction?肌联蛋白的修饰能否为射血分数保留的心力衰竭提供答案？
Circulation. 2016 Oct 11;134(15):1100-1104. doi: 10.1161/CIRCULATIONAHA.116.023648. Epub 2016 Sep 14.
2
Myocardial titin hypophosphorylation importantly contributes to heart failure with preserved ejection fraction in a rat metabolic risk model.肌联蛋白低磷酸化在代谢风险大鼠模型心力衰竭伴射血分数保留中起着重要作用。
Circ Heart Fail. 2013 Nov;6(6):1239-49. doi: 10.1161/CIRCHEARTFAILURE.113.000539. Epub 2013 Sep 6.
3
Mechanisms of diastolic dysfunction in heart failure with a preserved ejection fraction: If it's not one thing it's another.射血分数保留的心力衰竭中舒张功能障碍的机制：若非此因，便是彼故。
Circ Heart Fail. 2013 Nov;6(6):1112-5. doi: 10.1161/CIRCHEARTFAILURE.113.000825.
4
Response by Methawasin and Granzier to Letter Regarding Article, "Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Fraction".Methawasin和格兰齐尔对关于文章《通过RNA结合基序20（RBM20）抑制实验性增加肌联蛋白的顺应性可改善射血分数保留的心力衰竭小鼠模型的舒张功能》的信件的回复
Circulation. 2017 Mar 14;135(11):e681-e682. doi: 10.1161/CIRCULATIONAHA.117.026955.
5
Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction.通过抑制RNA结合基序20（RBM20）实验性增加肌联蛋白的顺应性可改善射血分数保留的心力衰竭小鼠模型的舒张功能。
Circulation. 2016 Oct 11;134(15):1085-1099. doi: 10.1161/CIRCULATIONAHA.116.023003. Epub 2016 Sep 14.
6
Letter by Lewis and Miller Regarding Article, "Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Fraction".刘易斯和米勒就文章《通过RNA结合基序20（RBM20）抑制实验性增加肌联蛋白的顺应性可改善射血分数保留的心力衰竭小鼠模型的舒张功能》所写的信函
Circulation. 2017 Mar 14;135(11):e679-e680. doi: 10.1161/CIRCULATIONAHA.116.025995.
7
Letter by Abu Daya et al Regarding Article, "Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction, Contributions of Collagen and Titin".阿布·达亚等人就题为《射血分数保留的心力衰竭患者的心肌僵硬度：胶原蛋白和肌联蛋白的作用》的文章所写的信
Circulation. 2015 Nov 24;132(21):e248. doi: 10.1161/CIRCULATIONAHA.115.017796.
8
Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn).肌联蛋白的可变剪接可恢复类似射血分数保留型心力衰竭遗传小鼠模型（TtnΔIAjxn）的舒张功能。
Circ Res. 2016 Sep 2;119(6):764-72. doi: 10.1161/CIRCRESAHA.116.308904. Epub 2016 Jul 28.
9
A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation.一种新型射血分数保留心力衰竭模式：合并症通过冠状动脉微血管内皮炎症导致心肌功能障碍和重构。
J Am Coll Cardiol. 2013 Jul 23;62(4):263-71. doi: 10.1016/j.jacc.2013.02.092. Epub 2013 May 15.
10
Microvascular Paradigm in Heart Failure With Preserved Ejection Fraction: A Quest for Proof of Concept.射血分数保留的心力衰竭中的微血管范式：寻求概念验证
Circ Heart Fail. 2017 Jun;10(6). doi: 10.1161/CIRCHEARTFAILURE.117.004179.

引用本文的文献

1
Modulation of Titin and Contraction-Regulating Proteins in a Rat Model of Heart Failure with Preserved Ejection Fraction: Limb vs. Diaphragmatic Muscle.在射血分数保留的心力衰竭大鼠模型中肌联蛋白和收缩调节蛋白的调节：肢体与膈肌肌肉。
Int J Mol Sci. 2024 Jun 16;25(12):6618. doi: 10.3390/ijms25126618.
2
Value of clinical applications of differential pressure and relative pressure imaging in the left ventricle.左心室压差与相对压力成像的临床应用价值
World J Clin Cases. 2023 Jun 16;11(17):3967-3975. doi: 10.12998/wjcc.v11.i17.3967.
3
Skeletal myopathy in a rat model of postmenopausal heart failure with preserved ejection fraction.

本文引用的文献

1
Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction.通过抑制RNA结合基序20（RBM20）实验性增加肌联蛋白的顺应性可改善射血分数保留的心力衰竭小鼠模型的舒张功能。
Circulation. 2016 Oct 11;134(15):1085-1099. doi: 10.1161/CIRCULATIONAHA.116.023003. Epub 2016 Sep 14.
2
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.射血分数保留的心力衰竭的表型特异性治疗：多器官路线图
Circulation. 2016 Jul 5;134(1):73-90. doi: 10.1161/CIRCULATIONAHA.116.021884.
3
绝经后射血分数保留型心力衰竭大鼠模型中的骨骼肌肌病。
J Appl Physiol (1985). 2022 Jan 1;132(1):106-125. doi: 10.1152/japplphysiol.00170.2021. Epub 2021 Nov 18.
4
Inflammatory and Molecular Pathways in Heart Failure-Ischemia, HFpEF and Transthyretin Cardiac Amyloidosis.心力衰竭中的炎症和分子途径——缺血、HFpEF 和转甲状腺素蛋白心脏淀粉样变性。
Int J Mol Sci. 2019 May 10;20(9):2322. doi: 10.3390/ijms20092322.
5
Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness.肾素-血管紧张素-醛固酮系统激活在促进心血管纤维化和僵硬中的作用。
Hypertension. 2018 Sep;72(3):537-548. doi: 10.1161/HYPERTENSIONAHA.118.11065.
6
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.组蛋白去乙酰化酶活性通过非基因组机制调控舒张功能障碍。
Sci Transl Med. 2018 Feb 7;10(427). doi: 10.1126/scitranslmed.aao0144.
7
Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease.基于等离子体纳米金芯片的自身抗体谱分析用于高血压性心脏病的早期检测。
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7089-7094. doi: 10.1073/pnas.1621457114. Epub 2017 Jun 19.
8
Role of mineralocorticoid receptor activation in cardiac diastolic dysfunction.醛固酮受体激活在心脏舒张功能障碍中的作用。
Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):2012-2018. doi: 10.1016/j.bbadis.2016.10.025. Epub 2016 Oct 29.
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.
2016欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南：欧洲心脏病学会（ESC）急性和慢性心力衰竭诊断与治疗特别工作组。由ESC心力衰竭协会（HFA）特别贡献制定。
Eur J Heart Fail. 2016 Aug;18(8):891-975. doi: 10.1002/ejhf.592. Epub 2016 May 20.
4
Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.单硝酸异山梨酯用于射血分数保留的心力衰竭患者
N Engl J Med. 2015 Dec 10;373(24):2314-24. doi: 10.1056/NEJMoa1510774. Epub 2015 Nov 8.
5
Heart failure preserved ejection fraction (HFpEF): an integrated and strategic review.射血分数保留的心力衰竭（HFpEF）：一项综合的策略性综述。
Heart Fail Rev. 2015 Nov;20(6):643-53. doi: 10.1007/s10741-015-9506-7.
6
Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin.射血分数保留的心力衰竭患者的心肌僵硬度：胶原蛋白和肌联蛋白的作用。
Circulation. 2015 Apr 7;131(14):1247-59. doi: 10.1161/CIRCULATIONAHA.114.013215. Epub 2015 Jan 30.
7
Cardiac titin and heart disease.心肌肌联蛋白与心脏病
J Cardiovasc Pharmacol. 2014 Mar;63(3):207-12. doi: 10.1097/FJC.0000000000000007.
8
Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.磷酸二酯酶-5 抑制剂对射血分数保留心力衰竭患者运动能力和临床状态的影响：一项随机临床试验。
JAMA. 2013 Mar 27;309(12):1268-77. doi: 10.1001/jama.2013.2024.
9
Titin is a major human disease gene.肌联蛋白是一种主要的人类疾病基因。
Circulation. 2013 Feb 26;127(8):938-44. doi: 10.1161/CIRCULATIONAHA.112.139717.
10
Myosin cross-bridge dynamics in patients with hypertension and concentric left ventricular remodeling.高血压和向心性左心室重构患者的肌球蛋白横桥动力学。
Circ Heart Fail. 2012 Nov;5(6):803-11. doi: 10.1161/CIRCHEARTFAILURE.112.968925. Epub 2012 Sep 26.