Wazir Umar, El Hage Chehade Hiba, Headon Hannah, Oteifa Medhat, Kasem Abdul, Mokbel Kefah
The London Breast Institute, The Princess Grace Hospital, London, U.K.
Kuwait Cancer Control Centre, Al Sabah Medical District, Shuwaikh, Kuwait.
Anticancer Res. 2016 Sep;36(9):4521-8. doi: 10.21873/anticanres.10999.
Lipofilling is an increasingly popular technique for breast reconstruction following both mastectomy and breast-conserving surgery (BCS). However, concerns remain over its oncological safety and its effect on cancer recurrence.
A systematic literature review and meta-analysis was carried out. Patients who had undergone mastectomy or BCS were investigated separately in order to find out whether the addition of lipofilling had a significant effect on locoregional recurrence rate.
Eleven studies were used in the analysis, yielding a total of 2,382 patients. For patients undergoing mastectomy (mean follow-up=36.2 months, range=12-90 months) or BCS (mean follow-up=30.2 months, range=12-60 months), the addition of lipofilling was not found to significantly affect the locoregional recurrence rate.
This meta-analysis demonstrates that lipofilling is an oncologically safe procedure to be incorporated into breast reconstruction following either mastectomy or BCS for breast cancer. However, a careful oncological follow-up is recommended. In the future, more adequately powered controlled clinical trials are needed in order to fully understand long-term outcomes after lipofilling.
脂肪填充是一种在乳房切除术后和保乳手术（BCS）后进行乳房重建越来越流行的技术。然而，其肿瘤学安全性及其对癌症复发的影响仍存在担忧。
进行了一项系统的文献综述和荟萃分析。分别对接受乳房切除术或保乳手术的患者进行调查，以确定脂肪填充的添加是否对局部区域复发率有显著影响。
分析中使用了11项研究，共纳入2382例患者。对于接受乳房切除术（平均随访=36.2个月，范围=12 - 90个月）或保乳手术（平均随访=30.2个月，范围=12 - 60个月）的患者，未发现脂肪填充的添加对局部区域复发率有显著影响。
这项荟萃分析表明，脂肪填充是一种肿瘤学安全的手术，可纳入乳腺癌乳房切除术后或保乳手术后的乳房重建。然而，建议进行仔细的肿瘤学随访。未来，需要更有足够效力的对照临床试验，以充分了解脂肪填充后的长期结果。
