Barbul A, Shawe T, Frankel H L, Efron J E, Wasserkrug H L
Department of Surgery, Sinai Hospital, Baltimore, MD 21215.
Surgery. 1989 Aug;106(2):373-6; discussion 376-7.
To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice. Groups of 10 mice underwent a 2.5 cm dorsal skin incision with subcutaneous placement of polyvinyl alcohol sponges. Starting on the day of wounding, the following daily injections were given: (1) thymopentin (TP5), an active synthetic pentapeptide of thymopoietin, a naturally occurring thymic hormone (1 microgram/day/IM); (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 microgram/day/IM); (3) control saline solution (0.1 ml/day/IM). All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured. The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice. The magnitude of the wound healing impairment induced by the two hormones was equal in the thymus-bearing and in the nude mice. The data support previous findings, which suggested that the thymus has an inhibitory effect on wound healing.
为了进一步明确胸腺在伤口愈合中的作用，我们研究了两种胸腺激素对正常有胸腺小鼠和无胸腺裸鼠纤维组织增生的影响。将10只小鼠分为一组，在其背部进行2.5厘米的皮肤切口，并在皮下植入聚乙烯醇海绵。从受伤当天开始，每天进行以下注射：（1）胸腺五肽（TP5），胸腺生成素的一种活性合成五肽，一种天然存在的胸腺激素（1微克/天/肌肉注射）；（2）胸腺素或血清胸腺因子（FTS），一种天然存在的循环胸腺激素（0.2微克/天/肌肉注射）；（3）对照生理盐水溶液（0.1毫升/天/肌肉注射）。所有小鼠在受伤4周后处死，测量伤口抗张强度和海绵肉芽肿的羟脯氨酸含量。结果表明，两种胸腺激素均损害了正常小鼠和无胸腺小鼠的伤口抗张强度和修复性胶原合成。两种激素诱导的伤口愈合损害程度在有胸腺小鼠和裸鼠中是相同的。这些数据支持了先前的研究结果，即胸腺对伤口愈合有抑制作用。
