Shah Naseem
Department of Dentistry, Hindu Rao Hospital, North Delhi Municipal Corporation Medical College, New Delhi, India.
Contemp Clin Dent. 2016 Jul-Sep;7(3):296-301. doi: 10.4103/0976-237X.188541.
To provide scientific evidence on the outcome of a large number of cases treated by SealBio over the longer follow-up period.
One hundred and thirty-four teeth in 116 patients presenting with pulp and periapical disease were randomly recruited between 2009 and 2014. SealBio was performed, and cases were followed up at regular intervals up to 6-year.
Of the total 134 teeth treated, 16 teeth could not be followed up and 9 cases failed (7.62% of cases). In only 4 cases (approximately 3.38% of cases), the failure could be directly attributed to endodontic causes. In the remaining 5 cases, coronal leakage from under the crown margins or dislodged restoration was found after 3-5 years of treatment.
SealBio was found to be a successful, nonobturation, regeneration-based endodontic treatment protocol. By cell homing of endogenous stem cells, a biological seal rather than an artificial seal with gutta-percha and sealer cement is possible to achieve. It is highly cost saving and easier to perform, in addition to other advantages, such as retreatment is much simpler, and postcore restoration is possible after SealBio treatment.
为SealBio治疗大量病例在较长随访期的结果提供科学证据。
2009年至2014年期间，随机招募了116例患有牙髓和根尖周疾病的患者的134颗牙齿。进行了SealBio治疗，并定期随访病例长达6年。
在总共治疗的134颗牙齿中，16颗牙齿无法随访，9例失败（占病例的7.62%）。仅在4例（约占病例的3.38%）中，失败可直接归因于牙髓病原因。在其余5例中，治疗3至5年后发现冠边缘下方的冠部渗漏或修复体移位。
SealBio被发现是一种成功的、非充填的、基于再生的牙髓治疗方案。通过内源性干细胞的细胞归巢，可以实现生物封闭而非用牙胶和封闭剂进行人工封闭。除了其他优点外，它还具有高度节省成本且操作更简便的特点，例如再治疗要简单得多，并且在SealBio治疗后可以进行桩核修复。
