Parhizkar Ardavan, Nojehdehian Hanieh, Asgary Saeed
Department of Dental Biomaterials, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iranian Center for Endodontic Research, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Restor Dent Endod. 2018 Jun 20;43(3):e28. doi: 10.5395/rde.2018.43.e28. eCollection 2018 Aug.
This study investigated the latest findings and notions regarding 'triple antibiotic paste' (TAP) and its applications in dentistry, particularly endodontics. TAP is a combination of 3 antibiotics, ciprofloxacin, metronidazole, and minocycline. Despite the problems and pitfalls research pertaining to this paste has unveiled, it has been vastly used in endodontic treatments. The paste's applications vary, from vital pulp therapy to the recently introduced regeneration and revascularisation protocol. Studies have shown that the paste can eliminate the root canal microorganisms and prepare an appropriate matrix for further treatments. This combination is able to remove diverse groups of obligate and facultative gram-positive and gram-negative bacteria, providing an environment for healing. In regeneration protocol cases, this allows the development, disinfection, and possible sterilization of the root canal system, so that new tissue can infiltrate and grow into the radicular area. Moreover, TAP is capable of creating a discipline in which other wanted and needed treatments can be successfully performed. In conclusion, TAP, as an antibacterial intracanal medication, has diverse uses. Nevertheless, despite its positive effects, the paste has shown drawbacks. Further research concerning the combined paste and other intracanal medications to control microbiota is a must.
本研究调查了关于“三联抗生素糊剂”（TAP）及其在牙科，特别是牙髓病学中的应用的最新发现和观点。TAP是环丙沙星、甲硝唑和米诺环素三种抗生素的组合。尽管有关这种糊剂的研究所揭示的问题和缺陷，但它已在牙髓治疗中被广泛使用。该糊剂的应用多种多样，从活髓治疗到最近引入的再生和血管化方案。研究表明，该糊剂可以消除根管微生物，并为进一步治疗准备合适的基质。这种组合能够去除各种专性和兼性革兰氏阳性和革兰氏阴性细菌，为愈合提供环境。在再生方案的病例中，这允许根管系统的发育、消毒和可能的灭菌，以便新组织能够浸润并生长到根尖区域。此外，TAP能够营造一种环境，使其他所需的治疗能够成功进行。总之，TAP作为一种根管内抗菌药物，有多种用途。然而，尽管有积极作用，但该糊剂也存在缺点。必须对联合糊剂和其他根管内药物进行进一步研究，以控制微生物群。
