CCL20的多种作用：聚焦乳腺癌
Many Roles of CCL20: Emphasis on Breast Cancer.
作者信息
Osuala Kingsley O, Sloane Bonnie F
机构信息
Wayne State University, Department of Pharmacology, School of Medicine, 540 E Canfield,Detroit, MI 48201, USA.
出版信息
Postdoc J. 2014 Mar;2(3):7-16.
Abstract
CCL20 or MIP3α is a small ~8 kDa protein primarily expressed in the liver, colon, prostate, cervix, and skin. The cellular receptor for CCL20 is CCR6. CCl20 unlike many other cytokines only binds CCR6, making the CCL20/CCR6 pathway an attractive drug target. Since the initial discovery of CCL20 in the early 1990's, there has been an increase in the evidence implicating the chemokine and its receptor in a number of diseases, including rheumatoid arthritis and human immunodeficiency virus infection. CCL20 has also been linked to malignancies such as ovarian, colorectal and pancreatic cancers. CCL20 can also attract tumor-promoting immune-suppressive cells to the tumor microenvironment, which may contribute to the immune evasive potential of the tumor and tumor progression.
摘要
CCL20或巨噬细胞炎性蛋白3α（MIP3α）是一种分子量约为8 kDa的小分子蛋白质，主要在肝脏、结肠、前列腺、子宫颈和皮肤中表达。CCL20的细胞受体是CCR6。与许多其他细胞因子不同，CCL20仅与CCR6结合，这使得CCL20/CCR6信号通路成为一个有吸引力的药物靶点。自20世纪90年代初首次发现CCL20以来，越来越多的证据表明这种趋化因子及其受体与多种疾病有关，包括类风湿性关节炎和人类免疫缺陷病毒感染。CCL20还与卵巢癌、结直肠癌和胰腺癌等恶性肿瘤有关。CCL20还可以将促进肿瘤生长的免疫抑制细胞吸引到肿瘤微环境中，这可能有助于肿瘤的免疫逃逸潜力和肿瘤进展。
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