Kaul A F, Federschneider J M, Stubblefield P G
J Reprod Med. 1978 Apr;20(4):213-8.
Women undergoing abortion by intraamniotic prostaglandin F2alpha were randomized to receive either prochlorperazine edisylate 10mg, hydroxyzine hydrochloride 100mg, or a placebo every four hours by intramuscular injection in a double-blind fashion. Vomiting was significantly more frequent in the placebo-treated group [0.2 +/- 1.5 SD episodes per patient, n=21] than in the groups treated with prochlorperazine [1.2 +/- 0.5 episodes per patient, n=21] or hydroxyzine [0.3 +/- 0.8 episodes per patient, n=19]. The mean number of merperidine injections in the antiemetic-treated groups was lower than in the control group, but this effect was not statistically significant. There was no significant difference between the treated and the control groups in the interval from prostaglandin treatment to abortion.
接受羊膜腔内注射前列腺素F2α进行流产的女性被随机分为三组，采用双盲方式每四小时肌肉注射一次，分别给予10毫克乙磺半胱氯丙嗪、100毫克盐酸羟嗪或安慰剂。安慰剂治疗组[每位患者0.2±1.5标准差发作次数，n = 21]的呕吐频率明显高于接受丙氯拉嗪治疗的组[每位患者1.2±0.5发作次数，n = 21]或羟嗪治疗的组[每位患者0.3±0.8发作次数，n = 19]。止吐治疗组哌替啶的平均注射次数低于对照组，但这种效果无统计学意义。治疗组和对照组在前列腺素治疗至流产的间隔时间上无显著差异。
