Kang Inhae, Buckner Teresa, Shay Neil F, Gu Liwei, Chung Soonkyu
Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE;
Department of Food Science and Technology, Oregon State University, Corvallis, OR; and.
Adv Nutr. 2016 Sep 15;7(5):961-72. doi: 10.3945/an.116.012575. Print 2016 Sep.
Ellagic acid (EA) is a naturally occurring polyphenol found in some fruits and nuts, including berries, pomegranates, grapes, and walnuts. EA has been investigated extensively because of its antiproliferative action in some cancers, along with its anti-inflammatory effects. A growing body of evidence suggests that the intake of EA is effective in attenuating obesity and ameliorating obesity-mediated metabolic complications, such as insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and atherosclerosis. In this review, we summarize how intake of EA regulates lipid metabolism in vitro and in vivo, and delineate the potential mechanisms of action of EA on obesity-mediated metabolic complications. We also discuss EA as an epigenetic effector, as well as a modulator of the gut microbiome, suggesting that EA may exert a broader spectrum of health benefits than has been demonstrated to date. Therefore, this review aims to suggest the potential metabolic benefits of consumption of EA-containing fruits and nuts against obesity-associated health conditions.
鞣花酸（EA）是一种天然存在的多酚，存在于一些水果和坚果中，包括浆果、石榴、葡萄和核桃。由于EA在某些癌症中具有抗增殖作用以及抗炎作用，因此对其进行了广泛研究。越来越多的证据表明，摄入EA可有效减轻肥胖并改善肥胖介导的代谢并发症，如胰岛素抵抗、2型糖尿病、非酒精性脂肪性肝病和动脉粥样硬化。在本综述中，我们总结了EA的摄入如何在体外和体内调节脂质代谢，并阐述了EA对肥胖介导的代谢并发症的潜在作用机制。我们还讨论了EA作为一种表观遗传效应物以及肠道微生物群调节剂的作用，这表明EA可能具有比迄今所证明的更广泛的健康益处。因此，本综述旨在提示食用富含EA的水果和坚果对肥胖相关健康状况的潜在代谢益处。
