Pinheiro Marina B, Ferreira Manuela L, Refshauge Kathryn, Hopper John, Maher Christopher G, Hartvigsen Jan, Koes Bart, Hübscher Markus, Ferreira Paulo H
Faculty of Health Sciences,The University of Sydney,Sydney,New South Wales,Australia.
The George Institute for Global Health & Institute of Bone and Joint Research/The Kolling Institute,Sydney Medical School,The University of Sydney,Sydney,Australia.
Twin Res Hum Genet. 2016 Oct;19(5):502-9. doi: 10.1017/thg.2016.68.
Low back pain (LBP) is a major health problem globally, but approaches to prevention are not yet clearly identified because modifiable risk factors are not well established. Although physical activity is one promising modifiable risk factor, it is still not known what types and doses of physical activity are protective or harmful for LBP. The aim of this study is to establish the feasibility of a definitive cohort study that will investigate the effects of different types and doses of physical activity on the risk of developing recurrent LBP while accounting for genetic factors. This will be a pilot longitudinal twin study and twins will be recruited from the Australian Twin Registry, and will be followed over 1 year. Thirty adult complete twin pairs with a history of LBP, but symptom free at recruitment, will be included. Data on physical activity (predictor) will be collected using four questionnaires and an objective measure (accelerometer) at baseline and at 6-month follow-up. Twins will also complete an additional physical activity questionnaire monthly. Data on LBP (outcome) will be collected at baseline and weekly. Data will be collected using short message service (SMS) and email. We will keep records of the recruitment rate, follow-up rate, and completeness of data. Barriers to completing the study will be investigated. The results of this study will inform the design and implementation of a future definitive study, which will help to clarify the effects of different types and doses of physical activity on the risk of developing recurrent LBP.
下背痛（LBP）是全球范围内的一个主要健康问题，但由于可改变的风险因素尚未明确确立，预防方法也尚未明确。尽管体育活动是一个有前景的可改变风险因素，但仍不清楚何种类型和剂量的体育活动对LBP具有保护作用或有害作用。本研究的目的是确定一项确定性队列研究的可行性，该研究将调查不同类型和剂量的体育活动对复发性LBP发生风险的影响，同时考虑遗传因素。这将是一项试点纵向双胞胎研究，双胞胎将从澳大利亚双胞胎登记处招募，并将随访1年。将纳入30对有LBP病史但在招募时无症状的成年同卵双胞胎。关于体育活动（预测因素）的数据将在基线和6个月随访时使用四份问卷和一种客观测量方法（加速度计）收集。双胞胎还将每月完成一份额外的体育活动问卷。关于LBP（结果）的数据将在基线和每周收集。数据将通过短信服务（SMS）和电子邮件收集。我们将记录招募率、随访率和数据完整性。将调查完成研究的障碍。本研究的结果将为未来确定性研究的设计和实施提供信息，这将有助于阐明不同类型和剂量的体育活动对复发性LBP发生风险的影响。
