Musculoskeletal Health Research Group, Faculty of Medicine and Health, School of Health Sciences, The University of Sydney, Sydney, New South Wales, Australia
Musculoskeletal Health Research Group, Faculty of Medicine and Health, School of Health Sciences, The University of Sydney, Sydney, New South Wales, Australia.
BMJ Open. 2020 Jul 28;10(7):e036301. doi: 10.1136/bmjopen-2019-036301.
Despite the growing evidence that physical activity and familial factors play a role in low back pain (LBP), there is a lack of robust longitudinal studies that (1) investigate the types and dosages of physical activity that are protective or harmful for LBP, (2) employ objective measures of physical activity and (3) conduct appropriate adjustment for confounders. The AUstralian Twin BACK (AUTBACK) study was established to elucidate the longitudinal LBP-physical activity relationship with the benefits of controlling for familial (both genetic/nongenetic) factors that may influence physical activity engagement and LBP.
Participants are twins registered at Twins Research Australia (TRA), older than 18 years, with access to internet. We collected data on LBP status (weekly) and physical activity levels (monthly) for 12 months as well as a wide range of health, lifestyle and physical activity (objective, self-reported, including different types and dosages) data.
We included 401 twins, 157 being complete twin pairs (n=314). Lifetime prevalence of LBP was 85%. Participants spent 61% of their week in sedentary time and only 4% in moderate/vigorous intensity physical activity (accelerometer). So far, 168 participants (40% of the sample) have completed the 12-month follow-up. A total of 7150 weekly (LBP status) and 1763 monthly questionnaires (physical activity status) have been answered (92% response rate).
The 12-month follow-up will be completed by June 2020. This cohort represents a novel and comprehensive resource for researchers in the field, and includes high-quality, and frequent data on LBP and physical activity. It allows the investigation of genetic and shared environmental factors on the LBP-physical activity relationship. The AUTBACK group has planned a number of projects, with the main one being the investigation of the influence of physical activity on recurrence of LBP. Data linkage opportunities are available, including with other studies conducted by TRA.
尽管越来越多的证据表明体力活动和家族因素在腰痛（LBP）中起作用，但缺乏强有力的纵向研究，这些研究（1）调查对 LBP 具有保护或有害作用的体力活动类型和剂量，（2）采用体力活动的客观测量方法，以及（3）对混杂因素进行适当调整。澳大利亚双胞胎背部研究（AUTBACK）旨在阐明纵向 LBP-体力活动关系，并受益于控制可能影响体力活动参与和 LBP 的家族（遗传/非遗传）因素。
参与者是在澳大利亚双胞胎研究协会（TRA）注册的年龄超过 18 岁且可以访问互联网的双胞胎。我们收集了 12 个月的 LBP 状况（每周）和体力活动水平（每月）的数据，以及广泛的健康、生活方式和体力活动（客观、自我报告，包括不同类型和剂量）数据。
我们纳入了 401 对双胞胎，其中 157 对是完整的双胞胎（n=314）。LBP 的终身患病率为 85%。参与者每周有 61%的时间处于久坐状态，只有 4%的时间处于中/高强度体力活动（加速度计）。到目前为止，已有 168 名参与者（样本的 40%）完成了 12 个月的随访。共回答了 7150 份每周（LBP 状况）和 1763 份每月（体力活动状况）问卷（响应率为 92%）。
12 个月的随访将于 2020 年 6 月完成。该队列代表了该领域研究人员的一项新颖而全面的资源，包括高质量和频繁的 LBP 和体力活动数据。它允许研究遗传和共享环境因素对 LBP-体力活动关系的影响。AUTBACK 小组计划了多个项目，其中主要项目是调查体力活动对 LBP 复发的影响。提供了数据链接机会，包括与 TRA 进行的其他研究。
